ACE2-independent infection of T lymphocytes by SARS-CoV-2

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Authors: Xu-Rui Shen, Rong Geng, Qian Li,  Ying Chen, Shu-Fen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, Yong Yang, Bei Li, Ren-Di Jiang, Xi Wang, Xiao-Shuang Zheng, Yan Zhu, Jing-Kun Jia, Xing-Lou Yang, Mei-Qin Liu, Qian-Chun Gong, Yu-Lan Zhang, Zhen-Qiong Guan, Hui-Ling Li, Zhen-Hua Zheng, Zheng-Li Shi, Hui-Lan Zhang, Ke Peng & Peng Zhou  Signal Transduction and Targeted Therapy volume 7, Article number: 83 (2022)  Abstract SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19. However, whether lymphocytes are targets of viral infection is […]

11 things doctors have learned about long COVID

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Authors: the UC Davis Post-COVID-19 clinic CORONAVIRUS February 11, 2022 Known to health experts as post-acute sequelae SARS-CoV-2 infection (PASC), it is more commonly known as long-haul COVID or long COVID. The Centers for Disease Control describes post-COVID conditions as ongoing or new symptoms occurring a month or more after a COVID-19 infection. It is estimated that between 10% to 30% of […]

Covid infections in Britain are rising again, and 90 percent of the dead are vaccinated. Have mRNA jabs ruined our chance at herd immunity?

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Authors: Alex Berenson New figures from Britain raise bright red flags about the direction of Covid in wealthy countries that used mRNA and DNA shots to attempt to defeat the coronavirus last year. Hospitalizations and deaths remain stubbornly high and overwhelmingly occur in vaccinated people. In February, 90 percent of the 1,000 Britons who died […]

Baricitinib for patients with severe COVID-19—time to change the standard of care?

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AuthorsAlexander Supadya,c,d and Robert Zeiserb Lancet Respir Med. 2022 Feb 3doi: 10.1016/S2213-2600(22)00021-2 [Epub ahead of print]PMCID: PMC8813061PMID: 35123659 Mortality is high among patients with severe COVID-19 who require invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO).1, 2 Therefore, further specific treatment options for these patients are urgently needed. Early in the COVID-19 pandemic, Janus kinase (JAK) inhibitors were identified as potential therapeutic agents […]

Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections

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Authors: Jonathan A. Stefely,Bianca B. Christensen,Tasos Gogakos,Jensyn K. Cone Sullivan … See all authors First published: 24 August 2020 https://doi.org/10.1002/ajh.25979 Abstract Coagulopathy causes morbidity and mortality in patients with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Yet, the mechanisms are unclear and biomarkers are limited. Early in the pandemic, we observed markedly elevated […]

Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

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Authors: Patrick J Lindsay, a Rachel Rosovsky, b Edward A Bittner, c and Marvin G. Chang c ABSTRACT Introduction COVID-19-associated coagulopathy (CAC) is a well-recognized hematologic complication among patients with severe COVID-19 disease, where macro- and micro-thrombosis can lead to multiorgan injury and failure. Major societal guidelines that have published on the management of CAC are based on consensus of expert opinion, with […]

Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series

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Ali Tabatabai 1, Joseph Rabin 2, Jay Menaker 2, Ronson Madathil 3, Samuel Galvagno 4, Ashley Menne 5, Jonathan H Chow 4, Alison Grazioli 6, Daniel Herr 1, Kenichi Tanaka 4, Thomas Scalea 2, Michael Mazzeffi 4Affiliations expand PMID: 32539272 PMCID: PMC7242090 DOI: 10.1213/XAA.0000000000001236 Abstract Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated […]

Whole genome sequencing reveals host factors underlying critical Covid-19

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Authors: Athanasios Kousathanas, Erola Pairo-Castineira, J. Kenneth BaillieArticle Published: 07 March 2022 nature  articles  article We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply. Abstract Critical Covid-19 is […]

COVID-19 targets human adrenal glands

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Authors: Waldemar Kanczkowski. Katja Evert. Marlena Stadtmüller, Martina Haberecker, Laura Laks, Lan-Sun Chen, et al. Published:November 18, 2021DOI:https://doi.org/10.1016/S2213-8587(21)00291-6PlumX Metrics COVID-19 develops due to infection with SARS-CoV-2, which particularly in elderly with certain comorbidities (eg, metabolic syndrome)1 can cause severe pneumonia and acute respiratory distress syndrome. Some patients with severe COVID-19 will develop a life-threatening sepsis with […]