C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps


Bruna M. Silva,1,2 Giovanni F. Gomes,1 Flavio P. Veras,1 Seppe Cambier,3 Gabriel V.L. Silva,1,2 Andreza U. Quadros,1 Diego B. Caetité,1,2 Daniele C. Nascimento,1,2 Camilla M. Silva,1,2 Juliana C. Silva,1 Samara Damasceno,1 Ayda H. Schneider,1 Fabio Beretta,3 Sabrina S. Batah,4 Icaro M.S. Castro,5 Isadora M. Paiva,1 Tamara…[...]

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19


Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn…[...]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis


James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 - 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and…[...]

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation


Julian Gonzalez-Rubio1* Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1, 3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian Cornelissen6 Mirko Trilling2 Anja Lena Thiebes1* Front. Bioeng. Biotechnology. , Sec. Tissue Engineering and Regenerative Medicine,…[...]

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition


Authors: Peng Pi1† Zhipeng Zeng1† Liqing Zeng1 Bing Han1 Xizhe Bai2 Shousheng Xu3*Front. Pharmacol., 03 August 2023, Sec. Respiratory Pharmacology, Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1218059 As the outbreak of COVID-19 caused by severe acute respiratory…[...]

Post-COVID Interstitial Lung Disease and Other Lung Sequelae


Mark Barash, DOa,∗ and Vijaya Ramalingam, MD, FCCPa,b Clin Chest Med. 2023 Jun; 44(2): 263–277. Published online 2023 Mar 3. doi: 10.1016/j.ccm.2022.11.019 PMCID: PMC9983785 PMID: 37085219 Author information Copyright and License information PMC Disclaimer As the world emerges from…[...]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg


Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion…[...]