Even With Breakthrough Cases, The Data Doesn’t Seem To Support Mask Mandates For Vaccinated People


The Center for Disease Control and Prevention’s (CDC) new mask guidance is based on newfound data suggesting vaccinated individuals can spread COVID-19, despite that data appearing to show that the…[...]

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality


Authors: Bandar Alosaimi1,2, Ayman Mubarak3, Maaweya E. Hamed3, Abdullah Z. Almutairi4, Ahmed A. Alrashed5, Abdullah AlJuryyan6, Mushira Enani7,Faris Q. Alenzi8 and Wael Alturaiki9* COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality.…[...]

The complement system in COVID-19: friend and foe?


Authors: Anuja Java,1 Anthony J. Apicelli,2 M. Kathryn Liszewski,3 Ariella Coler-Reilly,3 John P. Atkinson,3 Alfred H.J. Kim,3 and Hrishikesh S. Kulkarni4 Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted…[...]

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition


Authors: Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke,…[...]

Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders


Authors: Walid Alam Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic…[...]

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure


Authors: Monia Marchetti 1 COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction…[...]