The potential for antibody-dependent enhancement of SARS-CoV-2 infection: Translational implications for vaccine development

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Authors:  Jiong Wang andMartin S. Zand Published online by Cambridge University Press: 13 April 2020 Journal of Clinical and Translational Science>Volume 5 Issue 1 Abstract There is an urgent need for vaccines to the 2019 coronavirus (COVID19; SARS-CoV-2). Vaccine development may not be straightforward, due to antibody-dependent enhancement (ADE). Antibodies against viral surface proteins can, in some […]

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19

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Authors: Stephanie Seneff1 and Greg Nigh Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge MA, 02139, USA, E- Naturopathic Oncology, Immersion Health, Portland, OR 97214, ABSTRACT Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which […]

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

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Authors: Wen Shi Lee, Adam K. Wheatley, Stephen J. Kent & Brandon J. DeKosky  Nature Microbiology volume 5, pages1185–1191 (2020) Abstract Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). […]

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies

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Authors: Gabriela Athziri Sánchez-Zuno,1,†Mónica Guadalupe Matuz-Flores,1,†Guillermo González-Estevez,1Ferdinando Nicoletti,2Francisco Javier Turrubiates-Hernández,1Katia Mangano,2 and José Francisco Muñoz-Valle1 Int J Immunopathol Pharmacol. 2021 Jan-Dec; 35: 20587384211050199.Published online 2021 Oct 10. doi: 10.1177/20587384211050199PMCID: PMC8512237PMID: 34632844 Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the […]

Former Senior FDA Official: Manufacturers, FDA Negligent In Not Investigating Covid-19 Vaccine Risks To Heart Health

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Authors: DAVID GORTLER FEBRUARY 10, 2022 Manufacturers, FDA, and CDC must investigate serious cardiovascular incidents related to the Pfizer and Moderna Covid vaccines. From day ,one the U.S. Food and Drug Administration knew the Covid-19 vaccine was linked to serious heart trouble in recipients. The FDA medical officer review of Pfizer’s original Covid-19 application notes “clinically important […]

Long-term cardiovascular outcomes of COVID-19

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Authors: Yan Xie, Evan Xu, Benjamin Bowe & Ziyad Al-Aly  Nature Medicine (2022) Abstract The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from the US Department of Veterans Affairs to build a cohort of 153,760 individuals with […]

COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021

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Weekly / January 28, 2022 / 71(4);125–131 January 19, 2022, this report was posted online as an MMWR Early Release. Authors: Tomás M. León, PhD1; Vajeera Dorabawila, PhD2; Lauren Nelson, MPH1; Emily Lutterloh, MD2,3; Ursula E. Bauer, PhD2; Bryon Backenson, MPH2,3; Mary T. Bassett, MD2; Hannah Henry, MPH1; Brooke Bregman, MPH1; Claire M. Midgley, PhD4; Jennifer F. Myers, […]

1000 Peer Reviewed Studies Questioning Covid-19 Vaccine Safety

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Peer Reviewed Medical Papers Submitted To Various Medical Journals, Evidencing A Multitude Of Adverse Events In Covid-19 Vaccine Recipients. The list includes studies published as of January 20, 2022 concerning the potential adverse reaction from COVID-19 vaccines, such as myocarditis, thrombosis, thrombocytopenia, vasculitis, cardiac, Bell’s Palsy, immune-mediated disease, and many more. Myocarditis after mRNA vaccination […]

Myocarditis following mRNA vaccination against SARS-CoV-2, a case series

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Authors:William W.KingaMatthew R.PetersenaRalph M.MatarbJeffery B.BudwegaLydaCuervo PardocJohn W.Petersenb American Heart Journal Plus: Cardiology Research and Practice Volume 8, August 2021, 100042 Abstract Introduction mRNA COVID-19 vaccines have emerged as a new form of vaccination that has proven to be highly safe and effective against COVID-19 vaccination. Rare adverse events including myocarditis have been reported in the literature. […]

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

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Authors.Maximilian Ackermann, M.D., Stijn E. Verleden, Ph.D., Mark Kuehnel, Ph.D., Axel Haverich, M.D., Tobias Welte, M.D., Florian Laenger, M.D., Arno Vanstapel, Ph.D., Christopher Werlein, M.D., Helge Stark, Ph.D., Alexandar Tzankov, M.D., William W. Li, M.D., Vincent W. Li, M.D., et al. July 9, 2020 N Engl J Med 2020; 383:120-128 DOI: 10.1056/NEJMoa2015432 Abstract BACKGROUND Progressive respiratory failure is the primary cause of death in the coronavirus disease […]