SARS-CoV-2 infection: The role of cytokines in COVID-19 disease


Authors: Víctor J Costela-Ruiz 1, Rebeca Illescas-Montes 1, Jose M Puerta-Puerta 2, Concepción Ruiz 3, Lucia Melguizo-Rodríguez 1 COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of…[...]

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment


Authors: Mehmet Soy 1, Gökhan Keser 2, Pamir Atagündüz 3, Fehmi Tabak 4, Işık Atagündüz 5, Servet Kayhan COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes only mild symptoms in the majority of the cases,…[...]

Accumulating evidence suggests anti-TNF therapy needs to be given trial priority in COVID-19 treatment


Authors: Philip C Robinson, Duncan Richards, Helen L Tanner, Marc Feldmann The COVID-19 pandemic continues to wreak havoc on global health-care systems and to claim an increasing number of lives.…[...]

Pathways in the Pathophysiology of Coronavirus 19 Lung Disease Accessible to Prevention and Treatment


Authors: Michael Eisenhut 1, Jae Il Shin 2 Background: In COVID 19 related lung disease, which is a leading cause of death from this disease, cytokines like tumor necrosis factor-alpha (TNF alpha) may be…[...]

Integrative clinical, genomics and metabolomics data analysis for mainstream precision medicine to investigate COVID-19


Authors: Zeeshan Ahmed, Saman Zeeshan, David J Foran, Lawrence C Kleinman, Fredric E Wondisford,  XinQi Dong Crrespondence to Dr Zeeshan Ahmed, Rutgers Institute for Health, Health Care Policy and Aging Research, Rutgers University,…[...]

Genomics study identifies routes of transmission of coronavirus in care homes


Authors: Craig Brierley, University of Cambridge Genomic surveillance—using information about genetic differences between virus samples—can help identify how SARS-CoV-2 spreads in care home settings, whose residents are at particular risk, according…[...]