COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria


Authors: Gloria F. Gerber,1 Xuan Yuan,1 Jia Yu,1 Benjamin A.Y. Cher,2 Evan M. Braunstein,1 Shruti Chaturvedi,1 and Robert A. Brodsky1,* Complement has emerged as a likely driver of the immune response and end-organ damage in COVID-19. In…[...]

Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials


Authors: Musha Chen, Yue Yuan, Yiguo Zhou, Zhaomin Deng, Jin Zhao, Fengling Feng, Huachun Zou & Caijun Sun  Background Various modalities of vaccines against coronavirus disease 2019 (COVID-19), based on different platforms and immunization procedures, have been successively…[...]

COVID-19 Vaccine Safety in Adolescents Aged 12–17 Years — United States, December 14, 2020–July 16, 2021


Authors: Anne M. Hause, PhD1; Julianne Gee, MPH1; James Baggs, PhD1; Winston E. Abara, MD1; Paige Marquez, MSPH1; Deborah Thompson, MD2; John R. Su, MD, PhD1; Charles Licata, PhD1; Hannah…[...]

ADVERSE EFFECTS OF MESSENGER RNA VACCINES: An Evidence Review from the Penn Medicine Center for Evidence-based Practice


Authors: Project director: Nikhil K. Mull, MD (CEP), Lead analyst: Matthew D. Mitchell, PhD (CEP), Clinical review: Patrick J. Brennan, MD. (CMO) EVIDENCE SUMMARY: 1. There are no specific guidelines…[...]

SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy


Authors: C. Ferreras1†, B. Pascual-Miguel1†, C. Mestre-Durán1, A. Navarro-Zapata1, L. Clares-Villa1, C. Martín-Cortázar1, R. De Paz2, A. Marcos2, J. L. Vicario3, A. Balas3, F. García-Sánchez3, C. Eguizabal4,5, C. Solano6, M. Mora-Rillo7, B. Soria8,9 and A. Pérez-Martínez1,10,11* Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak…[...]

COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options


Authors: Larissa E van Eijk, 1 , † Mathijs Binkhorst, 2 , † Arno R Bourgonje, 3 , ‡ Annette K Offringa, 4 , ‡ Douwe J Mulder, 5 Eelke M Bos, 6 Nikola Kolundzic, 7 , 8 Amaal E Abdulle, 5 Peter HJ van der Voort, 9 Marcel GM Olde Rikkert, 10 Johannes G…[...]

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets


Authors: Williamson, Jack A. Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D. Davidson, David A. Matthews & Wendy S. Barclay SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2ʹ cleavage…[...]