COVID-19 and Brain Fog: A Possible Long-Term Effect


Authors: Robert John Sawyer, Ph.D Because COVID-19 is a new virus, it is too early to make definitive statements on how it affects the neurological system. New reports are raising concerns about lingering “brain fog” some COVID-19 patients are experiencing. These reports are shedding light on more short-term and, potentially, longer-term health consequences of COVID-19. Specifically, researchers are finding […]

Why Does COVID Make Some People So Sick, Ask Their Genome


Authors: Megan Molteni i SARS-COV-2,the pandemic coronavirus that surfaced for the first time in China last year, is an equal opportunity invader. If you’re a human, it wants in. Regardless of age, race, or sex, the virus appears to infect people at the same rate. Which makes sense, given that it’s a totally new pathogen against which approximately zero humans […]

COV-19 NCBI Genomics Basic: Unlocking capacities of viral genomics for the COVID-19 pandemic response


Authors: Sergey Knyazev,# Karishma Chhugani,# Varuni Sarwal,# Ram Ayyala,# Harman Singh,# Smruthi Karthikeyan, Dhrithi Deshpande, Zoia Comarova, Angela Lu, Yuri Porozov, Aiping Wu, Malak S. Abedalthagafi, Shivashankar H. Nagaraj, Adam L. Smith, Pavel Skums, Jason Ladner, Tommy Tsan-Yuk Lam, Nicholas C. Wu, Alex Zelikovsky, Rob Knight, Keith A. Crandall, and Serghei Mangul More than any other infectious disease epidemic, the COVID-19 pandemic has been characterized by the generation of large volumes of viral genomic data at […]

Elevated levels of a blood clotting factor linked to worse outcomes in severe COVID-19


Authors: MGH NEWS AND PUBLIC AFFAIRS This article is part of Harvard Medical School’s continuing coverage of medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19. Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood […]

COVID-19 presenting with diarrheas’ and hyponatremias


Authors: Fateen Ata, http://orcid.org/0000-0002-9549-8352Hussam Almasri, Jamal Sajid and http://orcid.org/0000-0002-4631-9899Zohaib Yousaf COVID-19 is a viral disease with a high infectivity rate. The full spectrum of the disease is not yet understood. This understanding may help in limiting potential exposure. We present a young man with diarrhoea, abdominal pain and hyponatraemia who turned out to be positive for COVID-19. This article […]

Cellular pathology in the COVID-19 era: a European perspective on maintaining quality and safety


Authors: John R Gosney1, http://orcid.org/0000-0003-0431-9353Paul Hofman2, http://orcid.org/0000-0003-1630-5805Giancarlo Troncone3, http://orcid.org/0000-0001-6813-0395Fernando Lopez-Rios4 COVID-19 is a zoonotic viral infection that originated in Wuhan, China, in late 2019. WHO classified the resulting pandemic as a ‘global health emergency’ due to its virulence and propensity to cause acute respiratory distress syndrome. The COVID-19 pandemic has had a major impact on diagnostic laboratories, particularly […]

What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses


Authors: Nirupa Gadi1,2, Samantha C. Wu1,2, Allison P. Spihlman1,2 and Vaishali R. Moulton1* The novel severe acute respiratory syndrome coronavirus 2, the cause of the coronavirus disease 2019 (COVID-19) pandemic, has ravaged the world, with over 22 million total cases and over 770,000 deaths worldwide as of August 18, 2020. While the elderly are most severely affected, implicating an […]

Extrapulmonary manifestations of COVID-19


Authors: Aakriti Gupta, Mahesh V. Madhavan, […]Donald W. Landry Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. […]

Viral dynamics in mild and severe cases of COVID-19


Authors: Lancet Correspondence Coronavirus disease 2019 (COVID-19) is a new pandemic disease. We previously reported that the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaks within the first week of disease onset.1, 2 Findings from Feb, 2020, indicated that the clinical spectrum of this disease can be very heterogeneous.3 Here, we report the viral RNA […]

Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression


Authors: Mary Kathryn Bohn, Alexandra Hall, Lusia Sepiashvili, Benjamin Jung, Shannon Steele, and Khosrow Adeli Abstract The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This […]