Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) – anatomic pathology perspective on current knowledge


Authors: Sambit K. Mohanty, Abhishek Satapathy, Machita M. Naidu, Sanjay Mukhopadhyay, Shivani Sharma, Lisa M. Barton, Edana Stroberg, Eric J. Duval, Dinesh Pradhan, Alexandar Tzankov & Anil V. Parwani  Abstract Background The world is currently witnessing a major devastating pandemic of…[...]

The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review


Authors: Shiqian Huang, Shuai Zhao, Huilin Luo, Zhouyang Wu, Jing Wu, Haifa Xia & Xiangdong Chen BMC Pulmonary Medicine volume 21, Article number: 116 (2021) Abstract Extracorporeal life support treatments such as extracorporeal membrane oxygenation (ECMO) have been recommended for the treatment of…[...]

What Does COVID Do to Your Blood?


Authors: Panagis Galiatsatos, M.D., M.H.S., Robert Brodsky, M.D. COVID-19 is a very complex illness. The coronavirus that causes COVID-19 attacks the body in many different ways, ranging from mild to…[...]

Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia


Authors: Francesco Taus, Gianluca Salvagno, Stefania Canè, Cristiano Fava, Fulvia Mazzaferri, Elena Carrara, Varvara Petrova, Roza Maria Barouni, Francesco Dima, Andrea Dalbeni, Simone Romano, Abstract Objective: Pulmonary thrombosis is observed in severe acute respiratory syndrome coronavirus 2 pneumonia. Aim was…[...]

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection


Authors: Lina Ma1, View ORCID ProfileSanjaya K. Sahu1, View ORCID ProfileMarlene Cano1, Vasanthan Kuppuswamy2, Jamal Bajwa1,3, View ORCID ProfileJa’Nia McPhatter1,4 Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2 infection. However, it remains…[...]

Sars cov 2 drives jak1 2 dependent local complement hyperactivation


Authors: Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry…[...]

SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells


Authors: Yuichiro J. Suzuki,a,⁎ Sofia I. Nikolaienko,b Vyacheslav A. Dibrova,b Yulia V. Dibrova,b Volodymyr M. Vasylyk,c Mykhailo Y. Novikov,d Nataliia V. Shults,a and Sergiy G. Gychkab Currently, the world is suffering from the pandemic of coronavirus disease 2019…[...]

COVID-19 Autopsies Put Endothelial Damage, Angiogenesis in the Spotlight


Authors: L.A. McKeown NEWSDaily News COVID-19 Autopsies Put Endothelial Damage, Angiogenesis in the Spotlight The still-forming picture suggests significantly more new-vessel growth in the lung than would be expected from…[...]

The Thorny Problem Of COVID-19 Vaccines And Spike Proteins


Authors: W. Glen Pyle Almost since the beginning of the COVID-19 pandemic, a piece of the SARS-CoV2 virus called the “spike protein” has drawn interest from researchers and healthcare professionals.…[...]