Category: Autoimmune Disease

Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity

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Authors: Lena F. Schimkea,5, Alexandre H.C. Marquesa, Gabriela Crispim Baiocchia, Caroline Aliane de Souza Pradob Dennyson Leandro M. Fonsecab , Paula Paccielli Freirea , Desirée Rodrigues Plaçab , Igor Salerno Filgueirasa ,Ranieri Coelho Salgadoa, Gabriel Jansen-Marquesc, Antonio Edson Rocha liveirab, Jean PierreSchatzmann Perona, José Alexandre Marzagão Barbutoa,d, Niels Olsen Saraiva Camaraa, Vera Lúcia Garcia Calicha […]

Good news: Mild COVID-19 induces lasting antibody protection

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People who have had mild illness develop antibody–producing cells that can last lifetime Authors: by Tamara Bhandari•May 24, 2021 Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine […]

COVID-19 Science Update released: June 4, 2021 Edition 92

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Authors: From the Office of the Chief Medical Officer, CDC COVID-19 Response, and the CDC Library, Atlanta GA. Intended for use by public health professionals responding to the COVID-19 pandemic. PEER-REVIEWED Safety, immunogenicity, and efficacy of the BNT162b2 COVID-19 vaccine in adolescents.external icon Frenck et al. NEJM (May 27, 2021). Key findings: Vaccine efficacy was 100% (95% CI 75.3%-100%) […]

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

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Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Abstract Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1,2,3,4,5,6,7. Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS-CoV-28,9,10. Nonetheless, […]

FDA Authorizes Covid Booster Shots For Immunocompromised Patients

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Authors: BY TYLER DURDEN After growing chatter over the past week, late on Thursday the U.S. Food and Drug Administration authorized booster shots for certain people with weakened immune systems, likely the launch of broader efforts to better protect against evasive variants like Delta. The agency said that other fully vaccinated individuals do not need […]

Adaptive immunity to SARS-CoV-2 and COVID-19

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Authors: Alessandro Sette1,2 and Shane Crotty1,2,* 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA2Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA92037, USA SUMMARYThe adaptive immune system is important for control of most viral […]

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

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Authors: Alessandro Sette 1 2, Shane Crotty 3 4 Abstract T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association […]

A long-term perspective on immunity to COVID

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Determining the duration of protective immunity to infection by SARS-CoV-2 is crucial for understanding and predicting the course of the COVID-19 pandemic. Clinical studies now indicate that immunity will be long-lasting. Authors: Andreas Radbruch & Hyun-Dong Chang Generating immunity against the SARS-CoV-2 coronavirus is of the utmost importance for bringing the COVID-19 pandemic under control, protecting vulnerable […]

Use of adenovirus type-5 vectored vaccines: a cautionary tale

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Authors: The Lancet We are writing to express concern about the use of a recombinant adenovirus type-5 (Ad5) vector for a COVID-19 phase 1 vaccine study,1 and subsequent advanced trials. Over a decade ago, we completed the Step and Phambili phase 2b studies that evaluated an Ad5 vectored HIV-1 vaccine administered in three immunizations for efficacy […]

Pros and Cons of Adenovirus-Based SARS-CoV-2 Vaccines

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Authors: Eric J. Kremer1,∗ Main Text Most of us might be surprised by the rudimentary scientific rationale prevalent in the field of vaccine research just 50 years ago. For over a century after Louis Pasteur’s vaccine against rabies, approaches usually consisted of inactivating a virus, injecting it, and seeing if it protected the host. Unlike […]