Adaptive immunity to SARS-CoV-2 and COVID-19


Authors: Alessandro Sette1,2 and Shane Crotty1,2,∗ Abstract The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infections and in vaccines, and […]

COVID-19 Makes B Cells Forget, but T Cells Remember


Authors: Pablo F Cañete 1, Carola G Vinuesa 2 Abstract Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS-CoV-2 infection may blunt long-lived antibody responses, immune memory might still be […]

Dr. Makary Says Natural Immunity Is More Effective Than Vaccine Immunity


Dr. Marty Makary, a professor at John Hopkins School of Medicine, during an appearance on The Vince Coglianese Show, said individuals formerly infected with COVID-19 are seven times more likely then vaccinated people to fight off the virus. “It appears that natural immunity is better against the Delta variant. When you get infected with COVID, […]

Complement control for COVID-19


Authors: Markus Bosmann1,2,3,4,* The complement system is an integral part of innate immune defense. It consists of about 50 proteins in plasma, on cell surfaces, and inside host cells. The traditional view is that complement proteins guard the local extracellular spaces and systemic bloodstream against invading pathogens. Loss-of-function mutations resulting in terminal complement pathway deficiencies […]