Authors: Israa A Alyousef,1Zainab A Alsaileek,1Manar A Alabdulsalam,1et. al. Cureus. 2022 Jan; 14(1): e21314. . doi: 10.7759/cureus.21314 PMCID: PMC8849467PMID: 35186573
Abstract
Coronavirus disease 2019 (COVID-19) typically involves the respiratory system, but gastrointestinal involvement is common. Further, patients with severe COVID-19 are at high risk to develop gastrointestinal complications, including bowel ischemia, ileus, and deranged liver enzymes. We present the case of a 44-year-old woman with mild COVID-19 pneumonia who was in home isolation. Ten days after the isolation, the patient presented to the emergency department complaining of generalized abdominal pain that was sharp in nature and associated with nausea and recurrent episodes of vomiting. The patient did not complain of any respiratory symptoms. Physical examination showed diffuse tenderness with no clinical signs to suggest generalized peritonitis. The laboratory parameters showed normal hematological, renal, and hepatic profiles. No elevation in the inflammatory markers was observed. The amylase level was within the normal range. Abdominal computed tomography scan demonstrated the presence of misty mesentery with increased density of the mesentery with fat stranding encasing the mesenteric vessels along with mesenteric adenopathy. Such radiological features suggested the diagnosis of mesenteric panniculitis. Subsequently, intravenous corticosteroid therapy was initiated and the patient exhibited significant improvement after 24 hours. The patient was discharged after nine days of hospitalization. She was followed up after one month and she had no complaints. Mesenteric panniculitis is a rare idiopathic inflammatory condition involving the mesenteric adipose tissue. The case shed a light on the possible association of COVID-19 with mesenteric panniculitis. The clinical manifestations of mesenteric panniculitis are non-specific and imaging studies are essential to suggest the diagnosis.Keywords: computed tomography, case report, mesenteric panniculitis, abdominal pain, covid-19
Introduction
Coronavirus disease 2019 (COVID-19) typically involves the respiratory system and manifests with fever, dyspnea, and cough. However, gastrointestinal symptoms in COVID-19 are common. It is reported that over 50% of patients reported at least one gastrointestinal symptom in addition to respiratory complaints [1]. Further, some reports suggested that the gastrointestinal symptoms may indeed precede the respiratory manifestations of COVID-19 [2]. Patients with COVID-19 who present with gastrointestinal symptoms tend to have a milder course of the disease [3]. However, patients with severe COVID-19 are at high risk to develop gastrointestinal complications, including bowel ischemia, ileus, and deranged liver enzymes [4]. A retrospective study by Giraudo et al. [5] involving 113 computed tomography scans of patients with confirmed COVID-19 pneumonia revealed that 13% of patients had increased attenuation of the mesenteric fat giving the appearance of “misty mesentery”. Here, we report the case of a patient on home isolation after COVID-19 pneumonia who developed acute abdominal pain due to mesenteric panniculitis.
Case presentation
A 44-year-old woman presented to the emergency department with a history of cough and fever for four days. The cough was not productive of sputum. The fever was constant and measured 38.1℃ in its peak. It was resolved by the use of oral paracetamol. Her symptoms were not associated with chest pain or dyspnea. She was otherwise healthy with no history of comorbid conditions. She was a non-smoker. The family and social history were non-contributory. The physical examination revealed normal oxygen saturation on room air with normal vital signs, including the pulse rate and respiratory rate. The patient had a body mass index of 28 kg/m2 (height 159 cm, weight 71 kg). Scattered crepitations were noted throughout both lung fields.
The patient underwent a reverse-transcriptase polymerase chain reaction test that was positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the patient’s symptoms were mild and she had no previous comorbid conditions, she was offered the option to have home isolation according to the national protocol.
Ten days later, the patient presented to the emergency department complaining of generalized abdominal pain that was sharp in nature and associated with nausea and recurrent episodes of vomiting. The patient did not complain of any respiratory symptoms. Physical examination showed diffuse tenderness with no clinical signs to suggest generalized peritonitis. The laboratory parameters showed normal hematological, renal, and hepatic profiles. No elevation in the inflammatory markers was observed on the initial and subsequent tests. The amylase level was within the normal range. The coagulation profile was normal.
The general surgery team was consulted and advised for an abdominal computed tomography scan. Subsequently, the contrast-enhanced computed tomography demonstrated the presence of misty mesentery with increased density of the mesentery with fat stranding encasing the mesenteric vessels along with mesenteric adenopathy (Figures (Figures1,1, ,2).2). Such radiological features suggested the diagnosis of mesenteric panniculitis.
Figure 1
Axial CT image shows increased attenuation of the mesenteric fat.
CT: computed tomography
Figure 2
Coronal CT image shows misty mesentery with increased density of the mesentery with fat stranding encasing the mesenteric vessels.
CT: computed tomography
Subsequently, intravenous corticosteroid therapy (intravenous methylprednisolone 40 mg) was initiated to prevent the progression of the disease and the fibrotic changes. The patient exhibited significant improvement in her symptoms after 24 hours from the treatment. The steroid therapy was continued for seven days with tapering down the dose. The patient was discharged after nine days of hospitalization. She was followed up after one month and she had no complaints.
Discussion
Mesenteric panniculitis is a rare benign non-specific inflammatory condition involving the intestinal mesentery. Mesenteric panniculitis is a rare condition with an average age of presentation in the seventh decade of life. It is twice as common in men as in women [6]. Considering the rarity of mesenteric panniculitis, its natural history is incompletely understood. The rate and risk factors of progression to the chronic stage are unknown. In the present case, since the patient had complete resolution of her symptoms, no further radiologic follow-up was performed to identify the presence of fibrosis changes.
The exact pathogenesis of mesenteric panniculitis remains unknown. However, several theories have been suggested. It is thought that mesenteric panniculitis develops as an inflammatory reaction following a prior abdominal surgery or trauma. This theory is supported by the finding of a cohort study showing that over 80% of patients with mesenteric panniculitis had a history of previous abdominal surgery [7]. Further, it has been suggested that a mesenteric panniculitis is a form of autoimmune condition targeting the adipose tissue of the mesentery. This is supported by the finding that some patients with mesenteric panniculitis have concomitant autoimmune disorders such as retroperitoneal fibrosis and primary sclerosing cholangitis. Additionally, mesenteric panniculitis can be a manifestation of paraneoplastic syndrome due to underlying malignancy [8,9]. However, in the present case, the patient had no history of any such risk factors, making the association between the panniculitis and COVID-19 more plausible. The SARS-CoV-2 virus uses the angiotensin-converting enzyme 2 (ACE2) as a receptor to invade human cells. Tissues with greater expression of ACE2 may become a target for the SARS-CoV-2. In addition to lung, the ACE2 is expressed in adipose tissue. Furthermore, it has been suggested that the expression of ACE2 in adipose tissue is higher than that in the lung tissue [10].
The majority of patients with mesenteric panniculitis have no clinical symptoms and their disease is diagnosed incidentally on imaging studies performed for unrelated indications [9]. Symptomatic patients have abdominal pain that could be associated with fever, nausea, vomiting, and weight loss [6]. In the chronic fibrosis stage of the disease, patients may present with intestinal obstruction. The laboratory markers may show elevation of the C-reactive protein to suggest an underlying inflammatory process [8]. However, laboratory investigation findings are non-specific and may be normal as in the present case. Patients should be started with immunosuppressive therapy with corticosteroid being the first-line regimen. Other agents include cyclophosphamide, which can be attempted if no clinical improvement was noted with the corticosteroid therapy. Surgery has a limited role such as a palliative procedure to relieve bowel obstruction [6,9].
Conclusions
Mesenteric panniculitis is a rare idiopathic inflammatory condition involving the mesenteric adipose tissue. The case shed a light on the possible association of COVID-19 with mesenteric panniculitis. The clinical manifestations of mesenteric panniculitis are non-specific and imaging studies are essential to suggest the diagnosis. Once the diagnosis is made, patients should be started on immunosuppressive therapy in order to prevent the chronic fibrotic changes of the disease.
Acknowledgments
Authors’ Contributions: IAA: literature review; ZAA: interpreted clinical data; MAA: prepared the radiological images; MAA: literature review; NAA: writing discussion; MMA: interpreted clinical data; AAA: writing introduction; MAA: writing discussion; HAF: prepared the radiological images; JIA: literature review; AMA: writing case presentation; ADA: writing introduction; AMA: writing case presentation; AJA: manuscript editing; FMA: overall supervision. All authors read and approved the final manuscript.
Notes
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research and reference purposes. Additionally, articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional. Do not disregard or avoid professional medical advice due to content published within Cureus.
References
1. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Pan L, Mu M, Yang P, et al. Am J Gastroenterol. 2020;115:766–773. [PMC free article] [PubMed] [Google Scholar]
2. Don’t overlook digestive symptoms in patients with 2019 novel coronavirus disease (COVID-19) Luo S, Zhang X, Xu H. Clin Gastroenterol Hepatol. 2020;18:1636–1637. [PMC free article] [PubMed] [Google Scholar]
3. Diarrhea is associated with prolonged symptoms and viral carriage in corona virus disease 2019. Wei XS, Wang X, Niu YR, et al. Clin Gastroenterol Hepatol. 2020;18:1753–1759. [PMC free article] [PubMed] [Google Scholar]
4. Gastrointestinal complications in critically ill patients with and without COVID-19. El Moheb M, Naar L, Christensen MA, Kapoen C, Maurer LR, Farhat M, Kaafarani HM. JAMA. 2020;324:1899–1901. [PMC free article] [PubMed] [Google Scholar]
5. It’s not just the lungs: COVID-19 and the misty mesentery sign. Giraudo C, Fichera G, Motta R, et al. Quant Imaging Med Surg. 2021;11:2201–2203. [PMC free article] [PubMed] [Google Scholar]
6. Clinical case of mesenteric panniculitis. Kniazkova I, Korchevskaya A, Bogun M. Reumatologia. 2019;57:297–300. [PMC free article] [PubMed] [Google Scholar]
7. Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity? Emory TS, Monihan JM, Carr NJ, Sobin LH. Am J Surg Pathol. 1997;21:392–398. [PubMed] [Google Scholar]
8. Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features. Nyberg L, Björk J, Björkdahl P, Ekberg O, Sjöberg K, Vigren L. BMC Gastroenterol. 2017;17:75. [PMC free article] [PubMed] [Google Scholar]
9. The complex relationship between mesenteric panniculitis and malignancy – a holistic approach is still needed to understand the diagnostic uncertainties. Meyyur Aravamudan V, Khan SR, Natarajan SK, Hussain I. Cureus. 2019;11:0. [PMC free article] [PubMed] [Google Scholar]
10. Abdominal surgery in patients with COVID-19: detection of SARS-CoV-2 in abdominal and adipose tissues. Safari S, Keyvani H, Malekpour Alamdari N, Dehghanian A, Razavi Hashemi M, Nemati Honar B, Aminian A. Ann Surg. 2020;272:0–6. [PMC free article] [PubMed] [Google Scholar]