Category: Lung Disease

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

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Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn Karhausen,4,11 and Ashley L. St. John1,4,12,13 Published August 10, 2023 – 10.1172/JCI149834 Journal of Clinical Investigation Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients […]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

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James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 – 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side […]

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

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Julian Gonzalez-Rubio1* Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1, 3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian Cornelissen6 Mirko Trilling2 Anja Lena Thiebes1* Front. Bioeng. Biotechnology. , Sec. Tissue Engineering and Regenerative Medicine, Volume 11 – 2023 | doi: 10.3389/fbioe.2023.1268782 The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, enters the […]

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

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Authors: Peng Pi1† Zhipeng Zeng1† Liqing Zeng1 Bing Han1 Xizhe Bai2 Shousheng Xu3*Front. Pharmacol., 03 August 2023, Sec. Respiratory Pharmacology, Volume 14 – 2023 | https://doi.org/10.3389/fphar.2023.1218059 As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in Hubei Province, China, at the end of 2019. It has brought great challenges and harms to global […]

Spectrum of Fibrotic Lung Diseases

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Marlies Wijsenbeek, M.D., and Vincent Cottin, M.D.  New England Journal of Medicine 2023 Diffuse parenchymal lung diseases encompass a large number of conditions, with a wide range of causes, clinical manifestations, and imaging and pathological features, as well as variable outcomes. Despite the intrinsic heterogeneity of this group of diseases, in most of them, the […]

COVID-19 Lung Damage

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Panagis Galiatsatos, M.D., M.H.S.  February 28, 2022  John’s Hopkins Like other respiratory illnesses, COVID-19 can cause lasting lung damage.  “As we continue to learn about COVID-19, we’re understanding more regarding how it affects the lungs during acute illness and afterward. And this is especially true with the virus’ ongoing variants, as well,” Galiatsatos says. What […]

Post-COVID Interstitial Lung Disease and Other Lung Sequelae

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Mark Barash, DOa,∗ and Vijaya Ramalingam, MD, FCCPa,b Clin Chest Med. 2023 Jun; 44(2): 263–277. Published online 2023 Mar 3. doi: 10.1016/j.ccm.2022.11.019 PMCID: PMC9983785 PMID: 37085219 Author information Copyright and License information PMC Disclaimer As the world emerges from the COVID-19 pandemic, clinicians and researchers across the world are trying to understand the sequelae in patients recovered from COVID-19 infection. In this article, the […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

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Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]

Post-COVID Interstitial Lung Disease: What you Need to Know

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Apr 28, 2023 Pulmonary Fibrosis Foundation After being hospitalized for three months with COVID-19 and double pneumonia in 2020, Houston police officer Hito Bazan awoke one morning to discover that he couldn’t talk, eat, walk, or most importantly, breathe. Bazan was diagnosed with interstitial lung disease (ILD) known as pulmonary fibrosis (PF). Three years into […]

COVID-19 Lung Damage

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Panagis Galiatsatos, M.D., M.H.S. February 28, 2022 Like other respiratory illnesses, COVID-19 can cause lasting lung damage. Panagis Galiatsatos, M.D., M.H.S., is an expert on lung disease at Johns Hopkins Bayview Medical Center and sees patients with COVID-19. He explains some of the short- and long-term lung problems brought on by the new coronavirus. “As […]