Authors: By Dr. Liji Thomas, MD The disease course of COVID-19 is diverse, ranging from asymptomatic to fatal respiratory failure. Emory University scientists have been working to uncover the immunological reasons […]
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
Authors: Gemma E Hartley 1, Emily S J Edwards 1, Pei M Aui 1, Nirupama Varese 1 2, Stephanie Stojanovic 3, James McMahon 4 5, Anton Y Peleg 4 6, Irene Boo 7, Heidi E Drummer 7 8 9, P Mark Hogarth 1 10 11, Robyn E O’Hehir 1 2 3, Menno C van Zelm 12 2 Abstract Lasting immunity following SARS-CoV-2 infection […]
Coronavirus: B cells and T cells explained
Authors: Beth Daley, Editor and General Manager To get the upper hand on the coronavirus, we first need to understand how our immune system reacts to it. Understanding this will […]
Lasting immunity found after recovery from COVID-19
Authors: References: Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, […]
COVID-19 Makes B Cells Forget, but T Cells Remember
Authors: Pablo F Cañete 1, Carola G Vinuesa 2 Abstract Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform […]
How B cells fight the COVID-19 virus
Authors: Sarah C.P. Williams A study of antibody-producing B cells from patients who recovered from COVID-19 reveals a new cross-reactive antibody and what makes some B cells more effective at […]
B cell memory: understanding COVID-19
Authors: Isaak Quast1 and David Tarlinton1,∗ Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defense strategy and underlie virtually all vaccine […]
SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy
Authors: C. Ferreras1†, B. Pascual-Miguel1†, C. Mestre-Durán1, A. Navarro-Zapata1, L. Clares-Villa1, C. Martín-Cortázar1, R. De Paz2, A. Marcos2, J. L. Vicario3, A. Balas3, F. García-Sánchez3, C. Eguizabal4,5, C. Solano6, M. Mora-Rillo7, B. Soria8,9 and A. Pérez-Martínez1,10,11* Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak […]
What is the role of T cells in COVID-19 infection? Why immunity is about more than antibodies
Summary CD4+ T cells help B cells to produce antibodies and help CD8+ T cells to kill virus-infected cells One of the dominant cytokines produced by T cells is interferon […]