Category: Autoimmune Disease

Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?

Posted on | Posted on John Murphy | Leave a Comment on Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?

Authors: Shotaro Tabata 1, Hiroki Hosoi 2, Shogo Murata 1, Satomi Takeda 1, Toshiki Mushino 1, Takashi Sonoki 1PMID: 34920343 PMCID: PMC8668346I: 10.1016/j.jaut.2021.102782 J Autoimmun. 2022 Jan; 126: 102782.Published online 2021 Dec 14. doi: 10.1016/j.jaut.2021.102782 Abstract The development of various autoimmune diseases has been reported after COVID-19 infections or vaccinations. However, no method for assessing the relationships between vaccines and the development of autoimmune diseases has been established. Aplastic anemia (AA) is […]

Bone Marrow Suppression Secondary to the COVID-19 Booster Vaccine: A Case Report

Posted on | Posted on John Murphy | Leave a Comment on Bone Marrow Suppression Secondary to the COVID-19 Booster Vaccine: A Case Report

Authors: Toral Shastri 1, Navkiran Randhawa 2, Ragia Aly 3, Masood Ghouse 3 PMID: 35210894 PMCID: PMC8863340DOI: 10.2147/JBM.S350290 Abstract As of September 2021, SARS-CoV-2 booster shots became widely available in the US to ensure continued protection against the virus. A temporal relationship has been previously reported between the first or second dose of the COVID-19 vaccine and the development of thrombocytopenia. However, adverse events related […]

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Nature volume 595, pages421–425 (2021) Abstract Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1,2,3,4,5,6,7. Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with […]

ACE2-independent infection of T lymphocytes by SARS-CoV-2

Posted on | Posted on John Murphy | Leave a Comment on ACE2-independent infection of T lymphocytes by SARS-CoV-2

Authors: Xu-Rui Shen, Rong Geng, Qian Li,  Ying Chen, Shu-Fen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, Yong Yang, Bei Li, Ren-Di Jiang, Xi Wang, Xiao-Shuang Zheng, Yan Zhu, Jing-Kun Jia, Xing-Lou Yang, Mei-Qin Liu, Qian-Chun Gong, Yu-Lan Zhang, Zhen-Qiong Guan, Hui-Ling Li, Zhen-Hua Zheng, Zheng-Li Shi, Hui-Lan Zhang, Ke Peng & Peng Zhou  Signal Transduction and Targeted Therapy volume 7, Article number: 83 (2022)  Abstract SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19. However, whether lymphocytes are targets of viral infection is […]

The potential for antibody-dependent enhancement of SARS-CoV-2 infection: Translational implications for vaccine development

Posted on | Posted on John Murphy | Leave a Comment on The potential for antibody-dependent enhancement of SARS-CoV-2 infection: Translational implications for vaccine development

Authors:  Jiong Wang andMartin S. Zand Published online by Cambridge University Press: 13 April 2020 Journal of Clinical and Translational Science>Volume 5 Issue 1 Abstract There is an urgent need for vaccines to the 2019 coronavirus (COVID19; SARS-CoV-2). Vaccine development may not be straightforward, due to antibody-dependent enhancement (ADE). Antibodies against viral surface proteins can, in some […]

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies

Posted on | Posted on John Murphy | Leave a Comment on A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies

Authors: Gabriela Athziri Sánchez-Zuno,1,†Mónica Guadalupe Matuz-Flores,1,†Guillermo González-Estevez,1Ferdinando Nicoletti,2Francisco Javier Turrubiates-Hernández,1Katia Mangano,2 and José Francisco Muñoz-Valle1 Int J Immunopathol Pharmacol. 2021 Jan-Dec; 35: 20587384211050199.Published online 2021 Oct 10. doi: 10.1177/20587384211050199PMCID: PMC8512237PMID: 34632844 Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the […]

COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021

Posted on | Posted on John Murphy | Leave a Comment on COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021

Weekly / January 28, 2022 / 71(4);125–131 January 19, 2022, this report was posted online as an MMWR Early Release. Authors: Tomás M. León, PhD1; Vajeera Dorabawila, PhD2; Lauren Nelson, MPH1; Emily Lutterloh, MD2,3; Ursula E. Bauer, PhD2; Bryon Backenson, MPH2,3; Mary T. Bassett, MD2; Hannah Henry, MPH1; Brooke Bregman, MPH1; Claire M. Midgley, PhD4; Jennifer F. Myers, […]

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

Posted on | Posted on John Murphy | Leave a Comment on Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

Authors: Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Tala Ballouz, Dominik Menges, Sara Hasler,  Sarah Adamo, Miro E. Raeber, Esther Bächli, Alain Rudiger, Melina Stüssi-Helbling, Lars C. Huber,  Jakob Nilsson, Ulrike Held, Milo A. Puhan & Onur Boyman  Nature Communications volume 13, Article number: 446 (2022)  Abstract Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, a serious condition termed post-acute coronavirus disease 2019 (COVID-19) […]

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae

Posted on | Posted on John Murphy | Leave a Comment on Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae

Authors: Yapeng Su 28, Dan Yuan 28, Daniel G. Chen 28,Mark M. Davis, Jason D. Goldman, James R. Heath 29 Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present with post-acute expansion of cytotoxic T cells […]

Necessity of COVID-19 Vaccination in Persons Who Have Already Had COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Necessity of COVID-19 Vaccination in Persons Who Have Already Had COVID-19

Authors: Nabin K Shrestha, Patrick C Burke, Amy S Nowacki, Paul Terpeluk, Steven M Gordon Clinical Infectious Diseases, ciac022, https://doi.org/10.1093/cid/ciac022 The purpose of this study was to evaluate the necessity of COVID-19 vaccination in persons with prior COVID-19.Methods Employees of Cleveland Clinic working in Ohio on Dec 16, 2020, the day COVID-19 vaccination was started, were included. Anyone who tested […]