Two-Year Longitudinal Study Reveals That Long COVID Symptoms Peak and Quality of Life Nadirs at 6–12 Months Postinfection 

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Zoe O Demko, Tong Yu, Sarika K Mullapudi, M Gabriela Varela Heslin, et. al. Open Forum Infectious Diseases, Volume 11, Issue 3, March 2024, ofae027, https://doi.org/10.1093/ofid/ofae027 Abstract Background Few longitudinal studies available characterize long COVID outcomes out to 24 months, especially in people with nonsevere acute coronavirus disease 2019 (COVID-19). This study sought to prospectively characterize incidence and duration of […]

Role of MicroRNA-21 in Regulating Intracellular Pathways Associated With Phagocytosis in Human Macrophages: An In Vitro Study

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Natsuki Anada • Yoshinobu Nakayama • Jun Takeshita • Kyoko Kageyama • Hiroatsu Sakamoto • Takahiko Kamibayashi • Yasufumi Nakajima 2024, DOI: 10.7759/cureus.63736  Abstract Introduction The efficient clearance of bacteria by macrophages is crucial for the timely resolution of inflammation. In this study, we investigated the role of microRNA-21 (miR-21)-induced phagocytosis and its intracellular signaling pathways in human macrophages in vitro. Methods Human peripheral blood mononuclear cells (PBMCs) were […]

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

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Shreya Ghimire, Biyun Xue, Kun Li, Ryan M Gannon, et. al.doi: https://doi.org/10.1101/2024.07.03.60194 Abstract Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modulating antibodies is variable and is affected by disease course and patient-specific inflammation patterns. Therefore, understanding the role of inflammation on the […]

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

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Carlos Garcia-Prieto, Eva Musulen, Veronica Davalos,  et. al.doi: https://doi.org/10.1101/2024.07.03.601404 00010010 Abstract Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to fatal outcomes. Characterizing DAD pathophysiology across disease progression is of ultimate importance to better understand the molecular and cellular features driving different DAD patterns and […]

Pfizer Infringed On Moderna Patent With COVID-19 Vaccine: Court

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JUL 05, 2024 – 07:00 PM, Authored by Zachary Stieber via The Epoch Times, Pfizer and BioNTech’s COVID-19 vaccine infringed on a patent held by rival Moderna, the High Court in London, England, found in a decision released on July 2. The Pfizer-BioNTech and Moderna COVID-19 vaccines both utilize messenger ribonucleic acid (mRNA) technology. Moderna […]

‘Visionary’ study finds inflammation, evidence of Covid virus years after infection

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By Isabella Cueto, 2024 Stat Reporting Remember when we thought Covid was a two-week illness? So does Michael Peluso, assistant professor of medicine at the University of California, San Francisco.  He recalls the rush to study acute Covid infection, and the crush of resulting papers. But Peluso, an HIV researcher, knew what his team excelled at: following […]

COVID-19 and spinal cord injury: clinical presentation, clinical course, and clinical outcomes of people hospitalised

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Inge E. Eriks-Hoogland, Michael A. Barth, Lorena L. Müller, et. al. Spinal Cord Series and Cases volume 10, Article number: 5 (2024)  Abstract Study design Retrospective study Objectives To describe the presenting symptoms/signs, clinical course and outcomes in hospitalised people with spinal cord injury (SCI) and symptomatic COVID-19 infections. Setting One university hospital and two SCI centres in Switzerland. Methods Descriptive analysis of […]

Acute Transverse Myelitis (ATM): An Unexpectedly Frequent Complication of COVID-19

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Todd Ackerman A Houston Methodist-led team of researchers have found COVID-19 can result in an unexpectedly frequent occurrence of acute transverse myelitis (ATM), a rare but often devastating spinal cord disorder. The team’s study of documented pandemic cases found that 43 involved ATM, an inflammation of the spinal cord that prevents sensory and motor information […]

Rapid Dissemination of Protocols for Managing Neurology Inpatients with COVID-19

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Authors: Anna Cervantes-Arslanian MD,K. H. Vincent Lau MD,Pria Anand MD, et. al. Annals of Neurology Volume 88, Issue 2 p. 211-214 Introduction In response to the coronavirus disease 2019 (COVID-19) pandemic, the scientific community has made great efforts to accelerate its process for knowledge synthesis and dissemination, including expedited journal peer review,1 open source platforms for quick […]

Prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome: A cross-sectional study

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Authors: Ahmed M. Eldokla,Aliae A. Mohamed-Hussein, Ahmed M. Fouad, et. al. 08 Annals of Clinical and Translational Neurology Volume 9, Issue 6 p. 778-785 Abstract Background The association between autonomic dysfunction and long-COVID syndrome is established. However, the prevalence and patterns of symptoms of dysautonomia in long-COVID syndrome in a large population are lacking. Objective To […]