Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

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Authors: Andrew F. Read ,Susan J. Baigent,Claire Powers,Lydia B. Kgosana,Luke Blackwell,Lorraine P. Smith,David A. Kennedy,Stephen W. Walkden-Brown,Venugopal K. Nair Abstract Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission […]

How Likely Are Vaccinated People To Get Meaningfully Sick From Delta?

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Authors: DYLAN HOUSMAN The reality that breakthrough cases exist and being vaccinated doesn’t guarantee protection from COVID-19 has raised a new question in the minds of many Americans: just how likely is it that someone will get seriously ill from the delta variant of COVID-19 if they are vaccinated? Some clinical data suggests that vaccine […]

Covid-19 Pandemic-Scared-Vaccinated

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Authors: Authored by Emily Miller via Emily Posts The Scared Vaccinated and the Grateful Vaccinated Fauci, CNN and Aniston are spokesmen for the Scared Vaccinated. Their opposites are the Grateful Vaccinated, who have little to worry about COVID. Nine out of 10 of the vaccinated will not catch the virus. That one “breakthrough” case will […]

What Does COVID Do to Your Blood?

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Authors: Panagis Galiatsatos, M.D., M.H.S., Robert Brodsky, M.D. COVID-19 is a very complex illness. The coronavirus that causes COVID-19 attacks the body in many different ways, ranging from mild to life threatening. Different organs and tissues of the body can be affected, including the blood. Robert Brodsky, a blood specialist who directs the Division of […]

How To Increase Platelet Count In COVID Patients? What Is Thrombocytopenia?

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Authors: Ananya Varma Platelets are said to play an important role in inflammatory signalling. Here is why it is important to keep a check of Platelet count in COVID patients.  Given that COVID-19 is a relatively novel disease, newer research continues to emerge into its characteristics with scientists now linking rapidly decreasing platelets to be a symptom of […]

Thrombocytopenia following Pfizer and Moderna SARS‐CoV‐2 vaccination

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Authors: Eun‐Ju Lee, 1 Douglas B. Cines, 2 Terry Gernsheimer, 3 Craig Kessler, 4 Marc Michel, 5 Michael D. Tarantino, 6 John W. Semple, 7 Donald M. Arnold, 8 Bertrand Godeau, 5 Michele P. Lambert, 9 , 10 and James B. Bussel 11 Cases of apparent secondary immune thrombocytopenia (ITP) after SARS‐CoV‐2 vaccination with both the Pfizer and Moderna versions have been reported and reached public attention. Public alarm was heightened following the death of the first identified […]

Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia

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Authors: Francesco Taus, Gianluca Salvagno, Stefania Canè, Cristiano Fava, Fulvia Mazzaferri, Elena Carrara, Varvara Petrova, Roza Maria Barouni, Francesco Dima, Andrea Dalbeni, Simone Romano, Abstract Objective: Pulmonary thrombosis is observed in severe acute respiratory syndrome coronavirus 2 pneumonia. Aim was to investigate whether subpopulations of platelets were programmed to procoagulant and inflammatory activities in coronavirus disease 2019 (COVID-19) patients with pneumonia, without comorbidities predisposing to […]

Platelet Gene Expression and Function in COVID-19 Patients

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Authors: Bhanu Kanth Manne (University of Utah, United States) Frederik Denorme (Molecular Medicine Program, University of Utah, United States), Elizabeth Middleton (University of Utah, United States), Irina Portier (University of Utah, United States) Jesse Rowley (University of Utah, United, States) Chris Stubben (University of Utah, United States) Aaron Petrey (University of Utah, United States) Neal […]

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

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Authors: Si Zhang 1, Yangyang Liu 2, Xiaofang Wang 2, Li Yang 3, Haishan Li 4, Yuyan Wang 5, Mengduan Liu 2, Xiaoyan Zhao 2, Youhua Xie 5, Yan Yang 6, Shenghui Zhang 7, Zhichao Fan 8, Jianzeng Dong 2, Zhenghong Yuan 5, Zhongren Ding 2, Yi Zhang 9, Liang Hu 10 Abstract Background: Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events and […]

The Impact of COVID-19 Disease on Platelets and Coagulation

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Authors: Geoffrey D Wool 1, Jonathan L Miller 2 Abstract Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and […]