Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Posted on | Posted on John Murphy | Leave a Comment on Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma Jowaly Schneider, et al. Published:January 12, 2022DOI:https://doi.org/10.1016/j.ebiom.2022.103812 Background Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods We obtained the lung specimens from the patients […]

Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients

Posted on | Posted on John Murphy | Leave a Comment on Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients

Authos: Ming Tong,1Yu Jiang,2Da Xia,3Ying Xiong,3Qing Zheng,4Fang Chen,2Lianhong Zou,2Wen Xiao,2 and Yimin Zhu2 J Infect Dis. 2020 Sep 15; 222(6): 894–898.Published online 2020 Jun 24. doi: 10.1093/infdis/jiaa349 PMCID: PMC7337874PMID: 32582936 Abstract In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. […]

What Role does Endothelial Infection Play in SARS-CoV-2 Infection?

Posted on | Posted on John Murphy | Leave a Comment on What Role does Endothelial Infection Play in SARS-CoV-2 Infection?

Authors: By Dr. Liji Thomas, MD Reviewed by Emily Henderson, B.Sc. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause inflammatory lung disease, including clot formation and hyper-permeability of the lung vessels, resulting in edema and bleeding into the lung. Inflammation also affects other organs, mediated by the cytokine storm. This inflammation is characterized by endothelial cell […]

Spike Proteins, COVID-19, and Vaccines

Posted on | Posted on John Murphy | Leave a Comment on Spike Proteins, COVID-19, and Vaccines

A new study further elucidates the role of spike proteins in COVID-19. Authors: Steven Novella  May 5, 2021 A recent study looks at the effects of the SARS-CoV-2 spike proteins, showing that they can cause some of the harm of COVID-19 by themselves. This is an important advance in our understanding of the disease and hopefully […]

DOD medical data reveals surges in oft-cited vax ‘adverse events’ in 2021

Posted on | Posted on John Murphy | Leave a Comment on DOD medical data reveals surges in oft-cited vax ‘adverse events’ in 2021

Three military doctors say medical billing code data captured by Defense Medical Epidemiology Database shows sharp spikes in miscarriages, myocarditis, cancer diagnoses, Bell’s palsy, female infertility. According to the data found by the military doctors, there was also a nearly 300% increase in cancer diagnoses, from a 38,700-per-year average in 2016-2020 to 114,645 in 2021. […]

Pandemic health consequences: Grasping the long COVID tail

Posted on | Posted on John Murphy | Leave a Comment on Pandemic health consequences: Grasping the long COVID tail

Authors: Kieran L. Quinn , Chaim M. Bell Published: January 25, 2022 Emerging evidence suggests that approximately 10% of people who survive Coronavirus Disease 2019 (COVID-19) will have lingering symptoms that negatively affect their quality of life, ability to work, and function [1,2]. This important group of people with the post-COVID-19 condition may seem small in comparison […]

Scientists Identify Factors That Appear Linked to Long Covid

Posted on | Posted on John Murphy | Leave a Comment on Scientists Identify Factors That Appear Linked to Long Covid

Authors: Marthe Fourcade 04:35 PM IST, 26 Jan 2022 06:47 PM IST, 26 Jan 2022 Scientists seeking to find out which patients are most at risk of developing long Covid offered partial answers in a study. People who have circulating fragments of the coronavirus, specific antibodies directed against their own tissues or organs — known […]

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

Posted on | Posted on John Murphy | Leave a Comment on Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

Authors: Matthew E. Oster, MD, MPH; David K. Shay, MD, MPH; John R. Su, MD, PhD, MPH; Julianne Gee, MPH; C. Buddy Creech, MD, MPH; Karen R. Broder, MD; Kathryn Edwards, MD; Jonathan H. Soslow, MD, MSCI; Jeffrey M. Dendy, MD; Elizabeth Schlaudecker, MD, MPH; Sean M. Lang, MD; Elizabeth D. Barnett, MD; Frederick L. […]

Antibody dependent enhancement: Unavoidable problems in vaccine development

Posted on | Posted on John Murphy | Leave a Comment on Antibody dependent enhancement: Unavoidable problems in vaccine development

Authors: Lele Xu, Zhiqian Ma, Yang Li, Zhaoxia Pang, and Shuqi Xiao* Adv Immunol. 2021; 151: 99–133.Published online 2021 Sep 4. doi: 10.1016/bs.ai.2021.08.003 PMCID: PMC8438590PMID: 34656289 Abstract In some cases, antibodies can enhance virus entry and replication in cells. This phenomenon is called antibody-dependent infection enhancement (ADE). ADE not only promotes the virus to be recognized by the target cell and enters the target […]

Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

Posted on | Posted on John Murphy | Leave a Comment on Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

Authors: Flor M. Munoz,a,⁎Jakob P. Cramer,bCornelia L. Dekker,cMatthew Z. Dudley,dBarney S. Graham,eMarc Gurwith,fBarbara Law,gStanley Perlman,hFernando P. Polack,iJonathan M. Spergel,jEva Van Braeckel,kBrian J. Ward,lArnaud M. Didierlaurent,mPaul Henri Lambert,m and for the Brighton Collaboration Vaccine-associated Enhanced Disease Working Group Abstract This is a Brighton Collaboration Case Definition of the term “Vaccine Associated Enhanced Disease” to be utilized in […]