Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Authors: Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu MaJowaly Schneider, et al. Published:January 12, 2022DOI:https://doi.org/10.1016/j.ebiom.2022.103812 Background Thromboembolism is a life-threatening manifestation of coronavirus disease 2019…[...]

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Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients

Authos: Ming Tong,1Yu Jiang,2Da Xia,3Ying Xiong,3Qing Zheng,4Fang Chen,2Lianhong Zou,2Wen Xiao,2 and Yimin Zhu2 J Infect Dis. 2020 Sep 15; 222(6): 894–898.Published online 2020 Jun 24. doi: 10.1093/infdis/jiaa349 PMCID: PMC7337874PMID: 32582936 Abstract In a retrospective study of 39…[...]

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Antibody dependent enhancement: Unavoidable problems in vaccine development

Authors: Lele Xu, Zhiqian Ma, Yang Li, Zhaoxia Pang, and Shuqi Xiao* Adv Immunol. 2021; 151: 99–133.Published online 2021 Sep 4. doi: 10.1016/bs.ai.2021.08.003 PMCID: PMC8438590PMID: 34656289 Abstract In some cases, antibodies can enhance virus entry and replication in cells.…[...]

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Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

Authors: Flor M. Munoz,a,⁎Jakob P. Cramer,bCornelia L. Dekker,cMatthew Z. Dudley,dBarney S. Graham,eMarc Gurwith,fBarbara Law,gStanley Perlman,hFernando P. Polack,iJonathan M. Spergel,jEva Van Braeckel,kBrian J. Ward,lArnaud M. Didierlaurent,mPaul Henri Lambert,m and for the Brighton…[...]

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