Authors: Clare Watson As many countries emerge from lockdowns, researchers are poised to use genome sequencing to avoid an expected second wave of COVID-19 infections. Since the first whole-genome sequence of the new coronavirus, SARS-CoV-2, was shared online on 11 January, scientists have sequenced and shared some 32,000 viral genomes from around the world. Such a vast amount […]
Authors: Giuseppe Novelli, Michela Biancolella, Ruty Mehrian-Shai, Vito Luigi Colona, Anderson F. Brito, Nathan D. Grubaugh, Vasilis Vasiliou, Lucio Luzzatto & Juergen K. V. Reichardt COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). […]
Authors: Executive Director Sharon Peacock The overarching aim of the project is to deliver large-scale SARS-CoV-2 sequencing to public health agencies, to inform interventions and policy decisions during the current pandemic; and all the other goals of COG-UK effectively feed into that. This sequencing capacity will enable close to real-time evaluation of novel treatments, vaccines […]
Authors: Patrick C Y Woo 1, Yi Huang, Susanna K P Lau, Kwok-Yung Yuen The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the largest genomes (26.4 to 31.7 kb) among all known RNA viruses, […]
Authors: Sergey Knyazev,# Karishma Chhugani,# Varuni Sarwal,# Ram Ayyala,# Harman Singh,# Smruthi Karthikeyan, Dhrithi Deshpande, Zoia Comarova, Angela Lu, Yuri Porozov, Aiping Wu, Malak S. Abedalthagafi, Shivashankar H. Nagaraj, Adam L. Smith, Pavel Skums, Jason Ladner, Tommy Tsan-Yuk Lam, Nicholas C. Wu, Alex Zelikovsky, Rob Knight, Keith A. Crandall, and Serghei Mangul More than any other infectious disease epidemic, the COVID-19 pandemic has been characterized by the generation of large volumes of viral genomic data at […]
Authors: MGH NEWS AND PUBLIC AFFAIRS This article is part of Harvard Medical School’s continuing coverage of medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19. Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood […]
Authors: Fateen Ata, http://orcid.org/0000-0002-9549-8352Hussam Almasri, Jamal Sajid and http://orcid.org/0000-0002-4631-9899Zohaib Yousaf COVID-19 is a viral disease with a high infectivity rate. The full spectrum of the disease is not yet understood. This understanding may help in limiting potential exposure. We present a young man with diarrhoea, abdominal pain and hyponatraemia who turned out to be positive for COVID-19. This article […]
Authors: Lindsey R. Baden, M.D., Hana M. El Sahly, M.D., Brandon Essink, M.D., Karen Kotloff, M.D., Sharon Frey, M.D., Rick Novak, M.D., David Diemert, M.D., Stephen A. Spector, M.D., Nadine Rouphael, M.D., C. Buddy Creech, M.D., John McGettigan, M.D., Shishir Khetan, M.D., et al., for the COVE Study Group* Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for […]
Authors: Romina Libster, M.D., Gonzalo Pérez Marc, M.D., Diego Wappner, M.D., Silvina Coviello, M.S., Alejandra Bianchi, Virginia Braem, Ignacio Esteban, M.D., Mauricio T. Caballero, M.D., Cristian Wood, M.D., Mabel Berrueta, M.D., Aníbal Rondan, M.D., Gabriela Lescano, M.D., et al., for the Fundación INFANT–COVID-19 Group* Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, […]
Authors: John R Gosney1, http://orcid.org/0000-0003-0431-9353Paul Hofman2, http://orcid.org/0000-0003-1630-5805Giancarlo Troncone3, http://orcid.org/0000-0001-6813-0395Fernando Lopez-Rios4 COVID-19 is a zoonotic viral infection that originated in Wuhan, China, in late 2019. WHO classified the resulting pandemic as a ‘global health emergency’ due to its virulence and propensity to cause acute respiratory distress syndrome. The COVID-19 pandemic has had a major impact on diagnostic laboratories, particularly […]