Antibody dependent enhancement: Unavoidable problems in vaccine development


Authors: Lele Xu, Zhiqian Ma, Yang Li, Zhaoxia Pang, and Shuqi Xiao* Adv Immunol. 2021; 151: 99–133.Published online 2021 Sep 4. doi: 10.1016/bs.ai.2021.08.003 PMCID: PMC8438590PMID: 34656289 Abstract In some cases, antibodies can enhance virus entry and replication in cells. This phenomenon is called antibody-dependent infection enhancement (ADE). ADE not only promotes the virus to be recognized by the target cell and enters the target […]

Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data


Authors: Flor M. Munoz,a,⁎Jakob P. Cramer,bCornelia L. Dekker,cMatthew Z. Dudley,dBarney S. Graham,eMarc Gurwith,fBarbara Law,gStanley Perlman,hFernando P. Polack,iJonathan M. Spergel,jEva Van Braeckel,kBrian J. Ward,lArnaud M. Didierlaurent,mPaul Henri Lambert,m and for the Brighton Collaboration Vaccine-associated Enhanced Disease Working Group Abstract This is a Brighton Collaboration Case Definition of the term “Vaccine Associated Enhanced Disease” to be utilized in […]

COVID virus linked with headaches, altered mental status in hospitalized kids


Authors: UNIVERSITY OF PITTSBURGH Peer-Reviewed Publication PITTSBURGH, Jan. 21, 2022 – Of hospitalized children who tested or were presumed positive for SARS-CoV-2, 44% developed neurological symptoms, and these kids were more likely to require intensive care than their peers who didn’t experience such symptoms, according to a new study led by a pediatrician-scientist at UPMC and the University […]

Public Health Scotland COVID-19 Winter Statistical Report


As at 17January 2022 Publication date: 19 January 2022 The latest public health data published by the Scottish Government reveals that the COVID-19 “age-standardized case rate” is at its highest among the double-jabbed ‘fully vaccinated’ – and it isn’t particularly close. The update also showed the sharp negative efficiency was maintained throughout double vaccinated rates for hospitalizations […]

COVID-19 vaccine surveillance report Week 3


Latest UK Data Shows Covid Infection RATE Among the Triple Jabbed (Boosted) Is HIGHER And RISING FASTER Than The Unvaccinated Across ALMOST EVERY Age Group 20 January 2022 Executive summaryFour coronavirus (COVID-19) vaccines have now been approved for use in the UK. Rigorousclinical trials have been undertaken to understand the immune response, safety profile andefficacy […]

American Scientists Confirm Toxic Graphene Oxide, and More, in Covid Injections


Authors: RHODA WILSON AUGUST 30, 2021   It is a human right, and global law governed under the Nuremberg Code, that vaccine specific ingredient information is disclosed.  It is critical, required and necessary information so anyone, from any country in the world, can make an informed decision whether or not to consent to medical intervention.  Because […]

Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives


Authors: Giovanni Genovese,a,bChiara Moltrasio,a,cEmilio Berti,a,b and Angelo Valerio Marzanoa,b,* Dermatology. 2020 Nov 24 : 1–12.Published online 2020 Nov 24. doi: 10.1159/000512932PMCID: PMC7801998PMID: 33232965 Abstract Background Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, […]

The novel coronavirus’ spike protein plays additional key role in illness


Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease April 30, 2021 LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins […]

Post-COVID ‘brain fog’ could be result of virus changing patients’ spinal fluid


Authors: by John Andere JANUARY 19, 2022 Cases of “brain fog” among COVID patients are becoming more and more common, even among people recovering from mild infections. Now, new research is finally providing some potential answers to why people have difficulty concentrating, thinking clearly, and completing easy daily tasks after battling COVID. A team from […]

Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design


Authors: Xuhua Xia1,2Kenneth Lundstrom, Academic Editor and Alaa. A. A. Aljabali, Academic Editor Abstract The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273 vaccine candidates are based on stabilized mRNA encoding prefusion SARS-2-S that can be produced after the mRNA […]