The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

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Authors:Jenny K.Stodola1GuillaumeDubois1AlainLe CoupanecMarcDesforgesPierre J.Talbot Highlights Coronavirus structural envelope (E) protein specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation are needed for optimal production of recombinant infectious virus.• Fully functional E protein of HCoV-OC43 is crucial for viral propagation in the CNS and neurovirulence.• Fully functional E protein of HCoV-OC43 is crucial […]

OC43 Membrane Protein Science

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UniProtKB – Q01455 (VME1_CVHOC) Entry Publications Feature viewer Feature table Function Names & Taxonomy Subcellular location Pathology & Biotech PTM / Processing Expression Interaction Structure Family & Domains Sequence Similar proteins Cross-references Entry information Miscellaneous TopBLASTAlignFormatAdd to basketHistory Membrane protein Gene M OrganismHuman coronavirus OC43 (HCoV-OC43)StatusReviewed-Annotation score:-Experimental evidence at protein leveli Functioni Component of the viral […]

Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation

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Authors: Frances W Lai 1, Kyle B Stephenson, James Mahony, Brian D Lichty Abstract The human coronavirus OC43 is a major contributor to the common cold worldwide, though due to its low mortality rate, little research has focused on this human pathogen. The nucleocapsid is an essential structural protein with conserved functions across the coronavirus family. While a multitude […]

Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

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Authors: Dr. Thomas E. Levy, MD, JD July 1, 2021 Although the mainstream media outlets might have you believe otherwise, the vaccines that continue to be administered for the COVID pandemic are emerging as substantial sources of morbidity and mortality themselves. While the degree to which these negative outcomes of the COVID vaccines can be debated, […]

The Lancet COVID-19 Resource Centre

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Welcome to the Lancet COVID-19 Resource Centre, bringing together all COVID-19 research, reviews, commentary, news, and analysis from across the Lancet family of journals as it is published. The resource aims to assist health workers, policy makers, and researchers to bring the COVID-19 pandemic to a close. All of our COVID-19 content is free to access. For More Information: […]

Long covid: Damage to multiple organs presents in young, low risk patients

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Authors: Gareth Iacobucci BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m4470 (Published 17 November 2020)Cite this as: BMJ 2020;371:m4470 Young, low risk patients with ongoing symptoms of covid-19 had signs of damage to multiple organs four months after initially being infected, a preprint study has suggested.1 Initial data from 201 patients suggest that almost 70% had impairments in one or more organs four months after […]

Attributes and predictors of long COVID

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Authors: Carole H. Sudre, Benjamin Murray, Claire J. Steves Abstract Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called ‘long COVID’, are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which […]

Long-Haul COVID

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 Authors: Avindra Nath Modern medicine has faced its biggest challenge from the smallest of organisms. It is becoming increasingly apparent that many patients who recovered from the acute phase of the SARS-CoV-2 infection have persistent symptoms. This includes clouding of mentation, sleep disturbances, exercise intolerance and autonomic symptoms (table 1). Some also complain of persistent […]

Study Finds Children Born During Lockdown Have Lost IQ Points, Impaired Cognitive Functioning

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Authors: by Paul Joseph Watson via Summit News, A new study has found that mean IQ scores of young children born during the pandemic have tumbled by as much as 22 points while verbal, motor and cognitive performance have all suffered as a result of lockdown. “With limited stimulation at home and less interaction with […]

As Their Numbers Grow, COVID-19 “Long Haulers” Stump Experts

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Authors: Rita Rubin, MA‘ For 32-year-old Hanna Lockman of Louisville, Kentucky, it all started March 12. She was at work when she suddenly felt a stabbing pain in her chest. “It just got worse and worse and worse, to the point I was crying from the pain,” she recalled in a recent interview. At 3 am, the pain […]