Swedish Professor Says 5 Shots Of COVID Vaccine May Be Necessary


While many people have bragged about being “fully vaccinated” after taking two COVID-19 jabs, a Swedish professor says that as many as five shots may be needed to combat falling immunity. “We don’t know how long the vaccine protects against serious illness and death,” said Karolinska Institute Professor Matti Sällberg. “This means that you pick the […]

The Astonishing Hubris Of A Global Experimental Vaccine


The Covid vaccines are experimental. The FDA has not approved them. Most vaccines require years to test and approve, in no small part because we want to make sure they don’t have dangerous long-term side effects, which they can have; the CDC has published a list of problems with selected approved vaccines. Many experimental vaccines never make it out of […]

Even With Breakthrough Cases, The Data Doesn’t Seem To Support Mask Mandates For Vaccinated People


The Center for Disease Control and Prevention’s (CDC) new mask guidance is based on newfound data suggesting vaccinated individuals can spread COVID-19, despite that data appearing to show that the vaccines still reduce infectiousness of the disease by some amount. When the CDC changed its mask guidance in late July to suggest that vaccinated people once again […]

COVID Cases In US Top 100,000 Per Day For First Time Since February


The Centers for Disease Control and Prevention (CDC) reported that COVID-19 cases in the U.S. have topped an average of greater than 100,000 per day for the first time since February. The daily case rate has not exceeded the levels of summer 2020 when vaccines were not available, however, the seven-day average of hospital admissions […]

CDC Director Tells CNN the COVID Vaccines Can’t Prevent Transmission


CDC Director and liberal mouthpiece Dr.Rochelle Walensky told Wolf Blitzer on Friday that the COVID vaccine cannot prevent the transmission of the disease. Dr. Rochelle Walensky: Our vaccines are working exceptionally well. They continue to work well for Delta in regard to severe illness and death being prevented. But what they can’t do anymore is prevent […]

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality


Authors: Bandar Alosaimi1,2, Ayman Mubarak3, Maaweya E. Hamed3, Abdullah Z. Almutairi4, Ahmed A. Alrashed5, Abdullah AlJuryyan6, Mushira Enani7,Faris Q. Alenzi8 and Wael Alturaiki9* COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve the complement pathway activation for cytokine storm development. Nevertheless, the role of complement in COVID-19 immunopathology, complement‐modulating treatment strategies against COVID-19, […]

The complement system in COVID-19: friend and foe?


Authors: Anuja Java,1 Anthony J. Apicelli,2 M. Kathryn Liszewski,3 Ariella Coler-Reilly,3 John P. Atkinson,3 Alfred H.J. Kim,3 and Hrishikesh S. Kulkarni4 Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19–related morbidity and mortality have been attributed to an exaggerated immune response. The role of complement […]

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition


Authors: Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial infarction, thrombocytopenia, and other end-organ damage. Animal models demonstrating end-organ protection in C3-deficient mice and evidence of complement activation in humans have […]

Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders


Authors: Walid Alam Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe respiratory failure. However, coagulation disorders have been found in some patients infected with SARS-CoV-2, leading to either a clotting disorder or hemorrhage. Several […]

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure


Authors: Monia Marchetti 1 COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL […]