Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity

Authors: Lena F. Schimkea,5, Alexandre H.C. Marquesa, Gabriela Crispim Baiocchia, Caroline Aliane de Souza Pradob Dennyson Leandro M. Fonsecab , Paula Paccielli Freirea , Desirée Rodrigues Plaçab , Igor Salerno…[...]

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SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Abstract Long-lived bone marrow plasma cells (BMPCs)…[...]

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Risk for COVID-19 Infection, Hospitalization, and Death By Age Group

Authors: CDC Rate ratios compared to 18- to 29-year-olds1  0-4 years old5-17 years old18-29 years old30-39 years old40-49 years old50-64 years old65-74 years old75-84 years old85+ years oldCases2<1x1xReference group1x1x1x1x1x1xHospitalization3<1x<1xReference group2x2x4x6x9x15xDeath4<1x<1xReference group4x10x35x95x230x600x All rates are relative to the 18- to…[...]

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Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19, March 2020–March 2021

Authors: Lyudmyla Kompaniyets, PhD1; Audrey F. Pennington, PhD1; Alyson B. Goodman, MD1,2; Hannah G. Rosenblum, MD1,3; Brook Belay, MD1; Jean Y. Ko, PhD1,2; Jennifer R. Chevinsky, MD1,3; Lyna Z. Schieber,…[...]

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Age-Adjusted Associations Between Comorbidity and Outcomes of COVID-19: A Review of the Evidence From the Early Stages of the Pandemic

Authors: Kate E. Mason*, Gillian Maudsley, Philip McHale, Andy Pennington, Jennifer Day and Ben Barr Objectives: Early in the COVID-19 pandemic, people with underlying comorbidities were overrepresented in hospitalised cases of COVID-19, but the relationship between comorbidity…[...]

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