Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

aUTHORS: Chien-Ting Wu,1,13Peter V. Lidsky,2,13Yinghong Xiao,2,13Ivan T. Lee,3,4,5,13Ran Cheng,1,6,13Tsuguhisa Nakayama,5,7,13Sizun Jiang,3,13Janos Demeter,1Romina J. Bevacqua,8Charles A. Chang,8,9,10,11Robert L. Whitener,8Anna K. Stalder,12Bokai Zhu,3Han Chen,3 Cell Metab. 2021 Aug 3; 33(8): 1565–1576.e5.Published online 2021…[...]

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Posted on | Posted on John Murphy | Leave a Comment on The Omicron subvariant BA.2: Birth of a new challenge during the COVID-19 pandemic

The Omicron subvariant BA.2: Birth of a new challenge during the COVID-19 pandemic

Authors: Farid Rahimia and Amin Talebi Bezmin Abadib,∗ Int J Surg. 2022 Mar; 99: 106261.Published online 2022 Feb12. doi: 10.1016/j.ijsu.2022.106261 PMCID: PMC8837492PMID: 35167986 In November 2021, many patients presented with the atypical pneumonia due to the severe…[...]

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Posted on | Posted on John Murphy | Leave a Comment on ACE2-independent infection of T lymphocytes by SARS-CoV-2

ACE2-independent infection of T lymphocytes by SARS-CoV-2

Authors: Xu-Rui Shen, Rong Geng, Qian Li,  Ying Chen, Shu-Fen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, Yong Yang, Bei Li, Ren-Di Jiang, Xi Wang, Xiao-Shuang Zheng, Yan Zhu, Jing-Kun Jia, Xing-Lou Yang, Mei-Qin Liu, Qian-Chun Gong, Yu-Lan Zhang, Zhen-Qiong Guan, Hui-Ling Li, Zhen-Hua Zheng, Zheng-Li Shi, Hui-Lan Zhang, Ke Peng & Peng Zhou …[...]

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Posted on | Posted on John Murphy | Leave a Comment on Covid infections in Britain are rising again, and 90 percent of the dead are vaccinated. Have mRNA jabs ruined our chance at herd immunity?

Covid infections in Britain are rising again, and 90 percent of the dead are vaccinated. Have mRNA jabs ruined our chance at herd immunity?

Authors: Alex Berenson New figures from Britain raise bright red flags about the direction of Covid in wealthy countries that used mRNA and DNA shots to attempt to defeat the…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Baricitinib for patients with severe COVID-19—time to change the standard of care?

Baricitinib for patients with severe COVID-19—time to change the standard of care?

AuthorsAlexander Supadya,c,d and Robert Zeiserb Lancet Respir Med. 2022 Feb 3doi: 10.1016/S2213-2600(22)00021-2 [Epub ahead of print]PMCID: PMC8813061PMID: 35123659 Mortality is high among patients with severe COVID-19 who require invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO).1, 2 Therefore,…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections

Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections

Authors: Jonathan A. Stefely,Bianca B. Christensen,Tasos Gogakos,Jensyn K. Cone Sullivan … See all authors First published: 24 August 2020 https://doi.org/10.1002/ajh.25979 Abstract Coagulopathy causes morbidity and mortality in patients with coronavirus disease 2019 (COVID-19) due…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

Authors: Patrick J Lindsay, a Rachel Rosovsky, b Edward A Bittner, c and Marvin G. Chang c ABSTRACT Introduction COVID-19-associated coagulopathy (CAC) is a well-recognized hematologic complication among patients with severe COVID-19 disease, where macro- and micro-thrombosis can…[...]

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