As Their Numbers Grow, COVID-19 “Long Haulers” Stump Experts


Authors: Rita Rubin, MA‘ For 32-year-old Hanna Lockman of Louisville, Kentucky, it all started March 12. She was at work when she suddenly felt a stabbing pain in her chest. “It just got worse and worse and worse, to the point I was crying from the pain,” she recalled in a recent interview. At 3 am, the pain […]

The Problem of ‘Long Haul’ COVID


More and more patients are dealing with major symptoms that linger for months Authors: By Carolyn Barber on December 29, 2020 It was just a couple of months into the pandemic when patients in online support groups began describing the phenomenon. In some emergency departments, they said, their complaints were largely being dismissed—or at the very least diminished—by […]

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis


Authors: Sandra Lopez-Leon, Talia Wegman-Ostrosky, Carol Perelman, Rosalinda Sepulveda, Paulina A. ebolledo, Angelica Cuapio & Sonia Villapol Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data […]

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—A Systemic Review and Comparison of Clinical Presentation and Symptomatology


Authors: Timothy L. Wong* and Danielle J. Weitzer Abstract Background and Objectives: Long COVID defines a series of chronic symptoms that patients may experience after resolution of acute COVID-19. Early reports from studies with patients with long COVID suggests a constellation of symptoms with similarities to another chronic medical illness—myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A review study comparing […]

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19


Authors: Pierre Kory, MD,1,*Gianfranco Umberto Meduri, MD,2Joseph Varon, MD,3Jose Iglesias, DO,4 and Paul E. Marik, MD5 Background: After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within […]

Pathological findings in organs and tissues of patients with COVID-19: A systematic review


Authors: Sasha Peiris, Hector Mesa, Agnes Aysola, Juan Manivel, Joao Toledo, Marcio Borges-Sa, Sylvain Aldighieri, Ludovic Reveiz Abstract Background Coronavirus disease (COVID-19) is the pandemic caused by SARS-CoV-2 that has caused more than 2.2 million deaths worldwide. We summarize the reported pathologic findings on biopsy and autopsy in patients with severe/fatal COVID-19 and documented the […]

Can we predict the severe course of COVID-19 – a systematic review and meta-analysis of indicators of clinical outcome?


Authors: Stephan Katzenschlager ,Alexandra J. Zimmer ,Claudius Gottschalk, Jürgen Grafeneder,Stephani Schmitz, Sara Kraker, Marlene Ganslmeier, Amelie Muth, Alexander Seitel, Lena Maier-Hein, Andrea Benedetti, Jan Larmann, Markus A. Weigand, Sean McGrath , Claudia M. Denkinger   Abstract Background COVID-19 has been reported in over 40million people globally with variable clinical outcomes. In this systematic review and meta-analysis, we assessed demographic, […]

Risk factors for severe and critically ill COVID-19 patients: A review


Authors: Ya-Dong Gao 1, Mei Ding 1 2, Xiang Dong 1, Jin-Jin Zhang 1, Ahmet Kursat Azkur 3, Dilek Azkur 4, Hui Gan 1, Yuan-Li Sun 1, Wei Fu 1, Wei Li 1, Hui-Ling Liang 1, Yi-Yuan Cao 5, Qi Yan 6, Can Cao 1, Hong-Yu Gao 6, Marie-Charlotte Brüggen 7 8 9, Willem van de Veen 2, Milena Sokolowska 2, Mübeccel Akdis 2, Cezmi A Akdis 2 Abstract The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high […]

Late Complications of COVID-19; a Systematic Review of Current Evidence


Authors: SeyedAhmad SeyedAlinaghi,1Amir Masoud Afsahi,2Mehrzad MohsseniPour,1Farzane Behnezhad,3Mohammad Amin Salehi,1Alireza Barzegary,4Pegah Mirzapour,1Esmaeil Mehraeen,5,* and Omid Dadras6 Introduction Introduction: COVID-19 is a new rapidly spreading epidemic. The symptoms of this disease could be diverse as the virus can affect any organ in the body of an infected person. This study aimed to investigate the available evidence for long-term complications […]

Better Anticoagulated Than Not! Hypercoagulability in COVID-19


Authors: Dhauna P. Karam, MD1 Incidence of thrombotic complications in patients with COVID-19 who are critically ill is high, with an estimated incidence of 31% for arterial or venous thromboembolism (VTE), acute pulmonary embolism, ischemic stroke, and myocardial infarction. On the basis of the study by Klok et al,1 pulmonary embolism was the most common thrombotic […]