Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Authors: MartinDugasa1TanjaGrote-Westrickb1UtaMerledMichaelaFontenaylmAndreas E.KremerhFrankHansesijRichardVollenbergcEvaLorentzenbShilpaTiwari-BecklerdJérômeDucheminlSyrineEllouzelMarcelVetterhJuliaFürsthPhilippSchusterkTobiasBrixaClaudia M.DenkingerfgCarstenMüller-TidoweHartmutSchmidtc…JoachimKühnb1 Highlights Does prior infection with seasonal human coronavirus OC43 protect against critical COVID-19?• Findings: In an international multi-center study inpatients without anti-HCoV OC43 NP antibodies had an increased risk of critical disease.• Meaning: Prior infections with seasonal HCoV OC43 have a protective effect against critical COVID-19. Abstract Background The vast majority of COVID-19 patients experience […]

What is OC43?

Posted on | Posted on John Murphy | Leave a Comment on What is OC43?

Authors: By Benedette Cuffari, M.Sc.Reviewed by Emily Henderson, B.Sc. In an effort to further understand and predict the health effects that can arise following infection by SARS-CoV-2, which is the infection that causes the disease COVID-19, many researchers have reevaluated the pathogenesis associated with coronaviruses that have already been identified. One type of coronavirus that has infected individuals around […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Authors: Martin Dugas 1, Tanja Grote-Westrick 2, Uta Merle 3, Michaela Fontenay 4, Andreas E Kremer 5, Frank Hanses 6, Richard Vollenberg 7, Eva Lorentzen 8, Shilpa Tiwari-Heckler 9, Jérôme Duchemin 10, Syrine Ellouze 11, Marcel Vetter 12, Julia Fürst 13, Philipp Schuster 14, Tobias Brix 15, Claudia M Denkinger 16, Carsten Müller-Tidow 17, Hartmut Schmidt 18, Phil-Robin Tepasse 19, Joachim Kühn 20 Abstract Background: The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. Objectives: To identify individuals at risk of critical COVID-19, […]

PubChem

Posted on | Posted on John Murphy | Leave a Comment on PubChem

OC43 Non-structural protein 2a NCBI Protein Q80872 Taxonomy Human coronavirus OC43 Dates Modify2021-08-11Create2017-04-15 UniProt 1Names and Identifiers 1.1Synonyms Non-structural protein 2a ns2a 32 kDa accessory protein 32 kDa non-structural protein ns2UniProt 1.2Other Identifiers 1.2.1UniProt ID Q80872UniProt 2Sequence >sp|Q80872|NS2A_CVHOC Non-structural protein 2a (Run BLAST) MAVAYADKPNHFINFPLTHFQGFVLNYKGLQFQILDEGVDCKIQTAPHISLTMLDIQPEDYKSVDVAIQEVIDDMHWGDGFQIKFENPHILGRCIVLDVKGVEELHDDLVNYIRDKGCVADQSRKWIGHCTIAQLTDAALSIKENVDFINSMQFNYKITINPSSPARLEIVKLGAEKKDGFYETIVSHWMGIRFEYTSPTDKLAMIMGYCCLDVVRKELEEGDLPENDDDAWFKLSYHYENNSWFFRHVYRKSFHFRKACQNLDCNCLGFYESPVEEDNCBI Protein For More Information: https://pubchem.ncbi.nlm.nih.gov/protein/Q80872

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

Posted on | Posted on John Murphy | Leave a Comment on The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

Authors:Jenny K.Stodola1GuillaumeDubois1AlainLe CoupanecMarcDesforgesPierre J.Talbot Highlights Coronavirus structural envelope (E) protein specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation are needed for optimal production of recombinant infectious virus.• Fully functional E protein of HCoV-OC43 is crucial for viral propagation in the CNS and neurovirulence.• Fully functional E protein of HCoV-OC43 is crucial […]

OC43 Membrane Protein Science

Posted on | Posted on John Murphy | Leave a Comment on OC43 Membrane Protein Science

UniProtKB – Q01455 (VME1_CVHOC) Entry Publications Feature viewer Feature table Function Names & Taxonomy Subcellular location Pathology & Biotech PTM / Processing Expression Interaction Structure Family & Domains Sequence Similar proteins Cross-references Entry information Miscellaneous TopBLASTAlignFormatAdd to basketHistory Membrane protein Gene M OrganismHuman coronavirus OC43 (HCoV-OC43)StatusReviewed-Annotation score:-Experimental evidence at protein leveli Functioni Component of the viral […]

Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation

Posted on | Posted on John Murphy | Leave a Comment on Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation

Authors: Frances W Lai 1, Kyle B Stephenson, James Mahony, Brian D Lichty Abstract The human coronavirus OC43 is a major contributor to the common cold worldwide, though due to its low mortality rate, little research has focused on this human pathogen. The nucleocapsid is an essential structural protein with conserved functions across the coronavirus family. While a multitude […]

Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

Posted on | Posted on John Murphy | Leave a Comment on Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

Authors: Dr. Thomas E. Levy, MD, JD July 1, 2021 Although the mainstream media outlets might have you believe otherwise, the vaccines that continue to be administered for the COVID pandemic are emerging as substantial sources of morbidity and mortality themselves. While the degree to which these negative outcomes of the COVID vaccines can be debated, […]

The Lancet COVID-19 Resource Centre

Posted on | Posted on John Murphy | Leave a Comment on The Lancet COVID-19 Resource Centre

Welcome to the Lancet COVID-19 Resource Centre, bringing together all COVID-19 research, reviews, commentary, news, and analysis from across the Lancet family of journals as it is published. The resource aims to assist health workers, policy makers, and researchers to bring the COVID-19 pandemic to a close. All of our COVID-19 content is free to access. For More Information: […]

Long covid: Damage to multiple organs presents in young, low risk patients

Posted on | Posted on John Murphy | Leave a Comment on Long covid: Damage to multiple organs presents in young, low risk patients

Authors: Gareth Iacobucci BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m4470 (Published 17 November 2020)Cite this as: BMJ 2020;371:m4470 Young, low risk patients with ongoing symptoms of covid-19 had signs of damage to multiple organs four months after initially being infected, a preprint study has suggested.1 Initial data from 201 patients suggest that almost 70% had impairments in one or more organs four months after […]