No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

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Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. https://doi.org/10.1172/JCI171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]

Systemic and organ-specific immune-related manifestations of COVID-19

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Manuel Ramos-Casals, Pilar Brito-Zerón & Xavier Mariette Nature Reviews Rheumatology volume 17, pages315–332 (2021) Cite this article Abstract Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS-CoV-2 infection is predominantly centred on the respiratory system, some patients can develop an […]

COVID-19 Therapeutics for Nonhospitalized Patients

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Rajesh T. Gandhi, MD1; Preeti N. Malani, MD, MSJ2,3; Carlos del Rio, MD4, JAMA. 2022;327(7):617-618. doi:10.1001/jama.2022.0335 Substantial progress has been made in therapeutics for nonhospitalized patients with COVID-19, but supply of and access to treatment remain limited. This Viewpoint summarizes currently available therapeutics for nonhospitalized patients in the setting of the Omicron variant including principles for equitable allocation. Patients with mild or moderate COVID-19 […]

US Survey: About 7% of Adults, 1% of Children Have Had Long COVID

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Emily Harris, JAMA. 2023;330(16):1516. doi:10.1001/jama.2023.19208 Medical News in Brief October 2023 JAMA Network More than 3% of US adults had post–COVID-19 condition, or long COVID, at the time of a 2022 National Health Interview Survey, and about 7% reported ever having had the condition, the Centers for Disease Control and Prevention recently announced. A similar trend held for children, […]

Hydroxychloroquine Associated With Lower COVID-19 Mortality: French Study

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NOV 03, 2023 – Authored by Zachary Stieber The Epoch Times  People who received hydroxychloroquine were less likely to die than those who did not, according to a new study. Just 0.8 percent of patients at a facility in France who received hydroxychloroquine (HCQ) and an antibiotic died, compared to 4.8 percent of patients who […]

The Veil Of Silence Over Excess Deaths

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OCT 30, 2023 Authored by Sonia Elijah via the Brownstone Institute, Around the world, there has been a deafening silence over excess deaths from governments and the mainstream media, who not so long ago were quite fixated on the daily death toll for Covid.  On October 20th, a 30-minute adjourned debate (20 rejections later) on excess deaths […]

Up to 50 Million Americans Believe They Have Had Long COVID: Study

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The mysterious condition may be wide-reaching Published 11/02/23, Mansur Shaheen, The Messenger Upwards of 50 million Americans could have experienced symptoms of long COVID at some point in the last three years, according to a new study. Researchers at the University College London, in England, gathered data from 461,550 people who completed a U.S. Census […]

COVID Origins Committee Chair: Officials Are Hiding Info From Americans

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The select subcommittee’s leader sat down with The Messenger to discuss the embattled search for the origin of COVID-19 Published 11/02/23 Mansur Shaheen The Messenger Ask anyone about the origins of COVID-19 and you might hear that it came from a wet market in Wuhan. Or a lab leak. Or bats. Or another animal entirely.     […]

European Regulator Confirms Pfizer Did Not Highlight DNA Sequence In COVID-19 Vaccine

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NOV 03, 2023 – Authored by Zachary Stieber The Epoch Times  Pfizer did not highlight a DNA sequence in its COVID-19 vaccine, a European regulator has confirmed. “While the full DNA sequence of the plasmid starting material was provided in the initial marketing authorization application for Comirnaty, the applicant did not specifically highlight the SV40 sequence,” the European […]

Serotonin reduction in post-acute sequelae of viral infection

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Andrea C. Wong, Ashwarya S. Devason, Iboro C. Umana, Sara Cherry, Christoph A. Thaiss, Maayan Levy 2Open Access Published:October 16, 2023DOI:https://doi.org/10.1016/j.cell.2023.09.013 Cell VOLUME 186, ISSUE 22, P4851-4867.E20, OCTOBER, 2023 Highlights Summary Post-acute sequelae of COVID-19 (PASC, “Long COVID”) pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several […]