Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn Karhausen,4,11 and Ashley L. St. John1,4,12,13 Published August 10, 2023 – 10.1172/JCI149834 Journal of Clinical Investigation Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients […]

Simvastatin in Critically Ill Patients with Covid-19

Posted on | Posted on John Murphy | Leave a Comment on Simvastatin in Critically Ill Patients with Covid-19

November 2, 2023, NEJM Abstract BACKGROUND The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients with Covid-19 who were not receiving statins […]

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

Posted on | Posted on John Murphy | Leave a Comment on Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

Siriruk Changrob,1 Peter J. Halfmann,2 Hejun Liu,3 Jonathan L. Torres,3 Joshua J.C. McGrath,1 Gabriel Ozorowski,3 Lei Li,1 G. Dewey Wilbanks,1 Makoto Kuroda,2 Tadashi Maemura,2 Min Huang,1 Nai-Ying Zheng,1 Hannah L. Turner,3 Steven A. Erickson,4 Yanbin Fu,1 Atsuhiro Yasuhara,1 Gagandeep Singh,5,6 Brian Monahan,6,7 Jacob Mauldin,6,7 Komal Srivastava,6,7 Viviana Simon,5,6,7,8,9 Florian Krammer,5,6,7 D. Noah Sather,10,11,12 Andrew B. Ward,3 Ian A. Wilson,3,13 Yoshihiro Kawaoka,2,14,15,16 and Patrick C. Wilson1,Published 2023 – 10.1172/JCI166844 Abstract The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants […]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

Posted on | Posted on John Murphy | Leave a Comment on Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 – 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side […]

Does the SARS-CoV-2 spike really have an Achilles heel?

Posted on | Posted on John Murphy | Leave a Comment on Does the SARS-CoV-2 spike really have an Achilles heel?

Shiv Pillai, Published , 2023 – More infoView PDF , 10.1172/JCI168080 Abstract The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a […]

The intersection of COVID-19 and autoimmunity

Posted on | Posted on John Murphy | Leave a Comment on The intersection of COVID-19 and autoimmunity

Jason S. Knight,1 Roberto Caricchio,2 Jean-Laurent Casanova,3,4,5,6 Alexis J. Combes,7 Betty Diamond,8 Sharon E. Fox,9,10 David A. Hanauer,11 Judith A. James,12 Yogendra Kanthi,13 Virginia Ladd,14 Puja Mehta,15 Aaron M. Ring,16 Ignacio Sanz,17 Carlo Selmi,18,19 Russell P. Tracy,20 Paul J. Utz,21 Catriona A. Wagner,14 Julia Y. Wang,22 and William J. McCune1,Published October 28, 2021 – Free access | 10.1172/JCI154886 Acute COVID-19, caused by SARS-CoV-2, is characterized by diverse clinical presentations, ranging from asymptomatic infection to fatal respiratory […]

Excess Deaths Associated with COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Excess Deaths Associated with COVID-19

Provisional Death Counts for COVID-19 NOTICE: THIS WEBSITE WAS ARCHIVED ON SEPTEMBER 27, 2023.Datasets linked on this page are available on data.cdc.gov. Please note that these datasets will no longer be updated after September 27, 2023. Provisional data is available on CDC WONDER (wonder.cdc.gov). Data are updated weekly, and users can query data by a […]

COVID Pandemic Caused Collective Trauma in Americans, Survey Says

Posted on | Posted on John Murphy | Leave a Comment on COVID Pandemic Caused Collective Trauma in Americans, Survey Says

Americans are more stressed than before, and experts blame COVID Published 11/03/23, Mansur Shaheen, The Messenger COVID Pandemic Caused Collective Trauma in Americans, Survey Says Americans, and specifically younger people, are much more stressed now than they were in years past. Experts say this is because of collective trauma experienced during the pandemic. A survey published Thursday […]

Ventilator-associated pneumonia in ICU patients with severe pneumonia and respiratory failure

Posted on | Posted on John Murphy | Leave a Comment on Ventilator-associated pneumonia in ICU patients with severe pneumonia and respiratory failure

Sarah Jackson Published June 15, 2023 – 10.1172/JCI172643 The Journal of Clinical Medicine The COVID-19 pandemic resulted in an unprecedented number of patients hospitalized in intensive care units (ICUs) because of severe SARS-CoV-2 infection (1). Respiratory failure in ICU patients, whether due to respiratory infection or other causes, may necessitate mechanical ventilation if oxygen levels cannot […]

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

Posted on | Posted on John Murphy | Leave a Comment on No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. https://doi.org/10.1172/JCI171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]