New Covid-19 Hospitalizations for 30- to 39-Year-Olds at Record Rate


Group largely avoided hospitals earlier in pandemic, but highly contagious Delta variant and lagging vaccination rates have changed health outcomes Authors: By Melanie Evans and Taylor Umlauf Hospitalizations of Covid-19 patients in their 30s have hit a new record, U.S. government data show, a sign of the toll that the highly contagious Delta variant is taking among the unvaccinated. Thirty-somethings, […]

Trained Innate Immunity, Epigenetics, and Covid-19


Authors: Alberto Mantovani, M.D., and Mihai G. Netea, M.D. Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens.1 Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the baseline tone of innate immunity and trigger […]

Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity


Authors: Lena F. Schimkea,5, Alexandre H.C. Marquesa, Gabriela Crispim Baiocchia, Caroline Aliane de Souza Pradob Dennyson Leandro M. Fonsecab , Paula Paccielli Freirea , Desirée Rodrigues Plaçab , Igor Salerno Filgueirasa ,Ranieri Coelho Salgadoa, Gabriel Jansen-Marquesc, Antonio Edson Rocha liveirab, Jean PierreSchatzmann Perona, José Alexandre Marzagão Barbutoa,d, Niels Olsen Saraiva Camaraa, Vera Lúcia Garcia Calicha […]

Good news: Mild COVID-19 induces lasting antibody protection


People who have had mild illness develop antibody–producing cells that can last lifetime Authors: by Tamara Bhandari•May 24, 2021 Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine […]

COVID-19 Science Update released: June 4, 2021 Edition 92


Authors: From the Office of the Chief Medical Officer, CDC COVID-19 Response, and the CDC Library, Atlanta GA. Intended for use by public health professionals responding to the COVID-19 pandemic. PEER-REVIEWED Safety, immunogenicity, and efficacy of the BNT162b2 COVID-19 vaccine in adolescents.external icon Frenck et al. NEJM (May 27, 2021). Key findings: Vaccine efficacy was 100% (95% CI 75.3%-100%) […]

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans


Authors: Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti & Ali H. Ellebedy  Abstract Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1,2,3,4,5,6,7. Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS-CoV-28,9,10. Nonetheless, […]

Why it’s time to move on from Covid


The Delta variant may have dashed hopes of herd immunity, but we can still live with the virus. Authors: DAVID LIVERMORE During the winter and spring the swiftly developed vaccines began to show startling success. Deaths from Covid fell, and severe side effects were rare. The UK rollout was among the most efficient in the […]

The most vaccine-hesitant group of all? PhDs


A new study found that the most educated are the least likely to get jabbed Authors: RAY HALL The percentage of each education group that is somewhat vaccine hesitant. Source: Carnegie Mellon University There has been much debate over how to get the unvaccinated to get their jabs — shame them, bribe them persuade them, or treat them as victims […]

Early COVID-19 symptoms differ among age groups, research finds


Authors: King’s College London Symptoms for early COVID-19 infection differ among age groups and between men and women, new research has found. These differences are most notable between younger age groups (16 to 59 years) compared to older age groups (60 to 80 years and over), and men have different symptoms compared to women in […]

Risk for COVID-19 Infection, Hospitalization, and Death By Age Group


Authors: CDC Rate ratios compared to 18- to 29-year-olds1   0-4 years old 5-17 years old 18-29 years old 30-39 years old 40-49 years old 50-64 years old 65-74 years old 75-84 years old 85+ years old Cases2 <1x 1x Reference group 1x 1x 1x 1x 1x 1x Hospitalization3 <1x <1x Reference group 2x 2x 4x 6x 9x 15x Death4 <1x <1x Reference group […]