Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression

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Authors: Mary Kathryn Bohn, Alexandra Hall, Lusia Sepiashvili, Benjamin Jung, Shannon Steele, and Khosrow Adeli Abstract The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This […]

Complications Coronavirus Can Cause

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Authors: WebMD If you have COVID-19, the illness that comes from infection with the recently discovered coronavirus, your symptoms may be relatively mild and manageable at home. That’s true for most people. But if you’re older or have another illness such as diabetes or heart disease, you’re more at risk for the serious form of COVID-19. Some people — about 1 […]

Interferons (Alfa, Beta)

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Authors: NIH Interferons are a family of cytokines with antiviral properties. They have been suggested as a potential treatment for COVID-19 because of their in vitro and in vivo antiviral properties. Recommendation The COVID-19 Treatment Guidelines Panel recommends against the use of interferons for the treatment of patients with severe or critical COVID-19, except in a clinical trial (AIII). There is insufficient evidence to […]

Cytokine Storm

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Authors: David C. Fajgenbaum, M.D., and Carl H. June, M.D. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reminded us of the critical role of an effective host immune response and the devastating effect of immune dysregulation. This year marks 10 years since the first description of a cytokine storm that developed after chimeric […]

Ivermectin

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Authors: NIH Ivermectin is a Food and Drug Administration (FDA)-approved antiparasitic drug that is used to treat several neglected tropical diseases, including onchocerciasis, helminthiases, and scabies.1 It is also being evaluated for its potential to reduce the rate of malaria transmission by killing mosquitoes that feed on treated humans and livestock.2 For these indications, ivermectin has been […]

OBGYN explains why a COVID vaccine might affect menstrual cycles

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Authors: Kate Larsen SAN FRANCISCO — Anecdotal evidence from women around the country has led to questions about how COVID-19 vaccines may affect women’s menstrual cycles. When ABC7 News reporter, Kate Larsen, posted the question on social media, it became clear that a lot of women are experiencing cycle changes, and are wondering if it’s […]

Coronavirus disease 2019 (COVID-19)

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Authors: Nicholas J. Beeching, MA, BM BCh, FRCP, FRACP, FFTM RCPS (Glasg), FESCMID, DCH, DTM&H, Tom E. Fletcher, MBE, PhD, MBChB, MRCP, DTM&H, Robert Fowler, MDCM, MS (Epi), FRCP(C) © BMJ Publishing Group 2021 Coronavirus disease 2019 (COVID-19) is an infectious acute respiratory disease caused by a novel coronavirus. The World Health Organization (WHO) was informed […]

COVID-19 (coronavirus): Long-term effects

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Authors: Mayo Clinic Staff COVID-19 symptoms can sometimes persist for months. The virus can damage the lungs, heart and brain, which increases the risk of long-term health problems. Most people who have coronavirus disease 2019 (COVID-19) recover completely within a few weeks. But some people — even those who had mild versions of the disease […]

Impact of COVID-19 and lockdown on mental health of children and adolescents: A narrative review with recommendations☆

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Authors: Shweta Singh,a Deblina Roy,b,⁎ Krittika Sinha,c Sheeba Parveen,c Ginni Sharma,c and Gunjan Josh COVID-19 pandemic and lockdown has brought about a sense of fear and anxiety around the globe. This phenomenon has led to short term as well as long term psychosocial and mental health implications for children and adolescents. The quality and magnitude of impact on minors is determined […]

Features, Evaluation, and Treatment of Coronavirus (COVID-19)

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Authors: Marco Cascella; Michael Rajnik; Abdul Aleem; Scott C. Dulebohn; Raffaela Di Napoli. Coronavirus disease 2019 (COVID-19), the highly contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on the world’s demographics resulting in more than 2.9 million deaths worldwide, emerging as the most consequential global health crisis since the era […]