Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn…[...]

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Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

Siriruk Changrob,1 Peter J. Halfmann,2 Hejun Liu,3 Jonathan L. Torres,3 Joshua J.C. McGrath,1 Gabriel Ozorowski,3 Lei Li,1 G. Dewey Wilbanks,1 Makoto Kuroda,2 Tadashi Maemura,2 Min Huang,1 Nai-Ying Zheng,1 Hannah L. Turner,3 Steven A. Erickson,4 Yanbin Fu,1 Atsuhiro Yasuhara,1 Gagandeep Singh,5,6 Brian Monahan,6,7 Jacob Mauldin,6,7 Komal Srivastava,6,7 Viviana Simon,5,6,7,8,9 Florian Krammer,5,6,7 D. Noah…[...]

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Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 - 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and…[...]

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The intersection of COVID-19 and autoimmunity

Jason S. Knight,1 Roberto Caricchio,2 Jean-Laurent Casanova,3,4,5,6 Alexis J. Combes,7 Betty Diamond,8 Sharon E. Fox,9,10 David A. Hanauer,11 Judith A. James,12 Yogendra Kanthi,13 Virginia Ladd,14 Puja Mehta,15 Aaron M. Ring,16 Ignacio Sanz,17 Carlo Selmi,18,19 Russell P. Tracy,20 Paul J. Utz,21 Catriona A. Wagner,14 Julia Y. Wang,22 and William J.…[...]

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No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 - September…[...]

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