6-month neurological and psychiatric outcomes in 236,379 survivors of COVID-19: a retrospective cohort study using electronic health records

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Authors: Maxime Taquet, John R Geddes, Masud Husain, Sierra Luciano, Paul J Harrison Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric […]

What do we know about covid vaccines and preventing transmission?

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BMJ 2022; 376 doi: https://doi.org/10.1136/bmj.o298  (Published 04 February 2022) Cite as:  BMJ 2022;376:o298 Authors: Chris Stokel-Walker, Vaccines that work against SARS-CoV-2 have helped change the course of the pandemic by reducing illness and hospital admissions. But Chris Stokel-Walker asks what we know about their impact on preventing transmission. The range of vaccines developed in record time by pharmaceutical companies and research laboratories […]

Sleep disorders and COVID-19

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Authors: Sushanth Bhata,∗ and Sudhansu Chokrovertyb Sleep Med. 2021 Jul 18doi: 10.1016/j.sleep.2021.07.021 Abstract This chapter summarizes the known associations between COVID-19 and sleep dysfunction, including insomnia, excessive daytime sleepiness, restless legs syndrome and nightmares, and touches upon pandemic-related considerations for obstructive sleep apnea and continuous positive airway pressure treatment. Treatment strategies and management approaches are also briefly discussed.Keywords: Coronasomnia, COVIDsomnia, […]

COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

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Authors: Eleonora Calabretta, 1 , 12 Jose M. Moraleda, 2 Massimo Iacobelli, 3 Ruben Jara, 4 Israel Vlodavsky, 5 Peter O’Gorman, 6 Antonio Pagliuca, 7 Clifton Mo, 8 Rebecca M. Baron, 9 Alessio Aghemo, 10 , 12 Robert Soiffer, 8 Jawed Fareed, 11 Carmelo Carlo‐Stella, 1 , 12 , * and Paul Richardson 8 , * Br J Haematol. 2021 Apr; 193(1): 43–51.Published online 2021 Feb 4.  doi:  10.1111/bjh.17240 PMCID:  PMC8014053PMID: 33538335 Introduction The coronavirus disease 2019 (COVID‐19) pandemic, a viral illness caused by the severe acute respiratory syndrome coronavirus‐2 […]

Ophthalmic Manifestations Of Coronavirus (COVID-19)

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Authors: Katherine Hu; Jay Patel; Cole Swiston; Bhupendra C. Patel. January 8, 2022. Introduction Since December 2019, coronavirus disease 2019 (COVID-19) has become a global pandemic caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[1] Initially, there were several reports of eye redness and irritation in COVID-19 patients, both anecdotal and published, supporting conjunctivitis as an ocular manifestation […]

The coagulopathy, endotheliopathy, and vasculitis of COVID-19

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Authors: Toshiaki Iba 1, Jean Marie Connors 2, Jerrold H Levy 3 PMID: 32918567 PMCID: PMC7486586 DOI: 10.1007/s00011-020-01401-6 Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the elevated D-dimer without remarkable changes of other global coagulation markers is associated with various thrombotic complications and disease severity. The purpose of this review is to elucidate the pathophysiology of this unique coagulopathy. Methods The authors performed […]

COVID-19-associated coagulopathy: An exploration of mechanisms

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Authors: Meaghan E Colling 1, Yogendra Kanthi 2 PMID: 32558620 PMCID: PMC7306998 OI: 10.1177/1358863X20932640 Abstract An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to the virus SARS-CoV-2, has infected millions of people and remains a threat to many more. Most critically ill patients have respiratory failure and there is an international effort to understand mechanisms and predictors of […]

Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

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Authors: Zhen W Mei, Xander M R van Wijk, Huy P Pham, Maximo J Marin The Journal of Applied Laboratory Medicine, Volume 6, Issue 5, September 2021, Pages 1305–1315,  https://doi.org/10.1093/jalm/jfab042Published: 13 June 2021 Abstract Background COVID-19, the disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can present with symptoms ranging from none to severe. Thrombotic events occur […]

Elevated P-Selectin in Severe Covid-19: Considerations for Therapeutic Options

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Authors: Chiara Agrati,1Veronica Bordoni,1Alessandra Sacchi,1Nicola Petrosillo,1Emanuele Nicastri,1Franca Del Nonno,1Gianpiero D’Offizi,1Fabrizio Palmieri,1Luisa Marchioni,1Maria Rosaria Capobianchi,1Andrea Antinori,1Giuseppe Ippolito,1 and Michele Bibas1 Mediterr J Hematol Infect Dis. 2021; 13(1): e2021016.Published online 2021 Mar 1.  doi:  10.4084/MJHID.2021.016 Abstract Background Coronavirus disease 2019 (COVID-19) is mainly a respiratory tract disease and acute respiratory failure with diffuse microvascular pulmonary thrombosis are critical aspects of […]

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

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Authors: Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Tala Ballouz, Dominik Menges, Sara Hasler,  Sarah Adamo, Miro E. Raeber, Esther Bächli, Alain Rudiger, Melina Stüssi-Helbling, Lars C. Huber,  Jakob Nilsson, Ulrike Held, Milo A. Puhan & Onur Boyman  Nature Communications volume 13, Article number: 446 (2022)  Abstract Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, a serious condition termed post-acute coronavirus disease 2019 (COVID-19) […]