Category: COVID-19

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy

SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy

Authors: C. Ferreras1†, B. Pascual-Miguel1†, C. Mestre-Durán1, A. Navarro-Zapata1, L. Clares-Villa1, C. Martín-Cortázar1, R. De Paz2, A. Marcos2, J. L. Vicario3, A. Balas3, F. García-Sánchez3, C. Eguizabal4,5, C. Solano6, M. Mora-Rillo7, B. Soria8,9 and A. Pérez-Martínez1,10,11* Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak…[...]

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Posted on | Posted on John Murphy | Leave a Comment on COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options

COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options

Authors: Larissa E van Eijk, 1 , † Mathijs Binkhorst, 2 , † Arno R Bourgonje, 3 , ‡ Annette K Offringa, 4 , ‡ Douwe J Mulder, 5 Eelke M Bos, 6 Nikola Kolundzic, 7 , 8 Amaal E Abdulle, 5 Peter HJ van der Voort, 9 Marcel GM Olde Rikkert, 10 Johannes G…[...]

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Posted on | Posted on John Murphy | Leave a Comment on The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Authors: Williamson, Jack A. Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D. Davidson, David A. Matthews & Wendy S. Barclay SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2ʹ cleavage…[...]

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Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Authors: Yuyang Lei, Jiao Zhang, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X., et. al. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection…[...]

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