Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

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Authors: Ger T. Rijkers,1,2,* Nynke Weterings,1 Andres Obregon-Henao,3 Michaëla Lepolder,1 Taru S. Dutt,3 Frans J. van Overveld,1 and Marcela Henao-Tamayo3 Abstract Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A number of effective vaccines have been produced, including mRNA vaccines and viral vector vaccines, which are now being implemented on a […]

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

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Authors: Yuyang Lei,1,2,*Jiao Zhang,1,2,5,*Cara R. Schiavon,8,9Ming He,5Lili Chen,2Hui Shen,5,10Yichi Zhang,5Qian Yin,2Yoshitake Cho,5Leonardo Andrade,8Gerald S. Shadel,9Mark Hepokoski,6Ting Lei,3Hongliang Wang,4Jin Zhang,7Jason X.-J. Yuan,6Atul Malhotra,6Uri Manor,8,†Shengpeng Wang,2,†Zu-Yi Yuan,1,† and John Y-J. Shyy5,† SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium […]

THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS

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Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very […]

VAERS Summary for COVID-19 Vaccines through 11/05/2021

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Official Reported Vaccine Adverse Events in the FDA Data Base For a Complete Report of All Vaccine Reported Adverse Events Through November 5th, 2021 Click Link Below: http://vaersanalysis.info/wp-content/uploads/2021/11/VAERS-Summary-11052021-3.pdf

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalizations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

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Eric J HaasFrederick J AnguloJohn M McLaughlinEmilia AnisShepherd R SingerFarid KhanNati BrooksMeir SmajaGabriel MircusKaijie PanJo SouthernDavid L SwerdlowLuis JodarYeheskel LevySharon Alroy-PreisAuthors: During the analysis period (Jan 24 to April 3, 2021), there were 232 268 SARS-CoV-2 infections, 7694 COVID-19 hospitalizations, 4481 severe or critical COVID-19 hospitalizations, and 1113 COVID-19 deaths in people aged 16 years […]

Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

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Authors: Sara YTartofPhDaeJeff MSlezakMSaHeidiFischerPhDaVennisHongMPHaBradley KAckersonMDbOmesh NRanasingheMPHaTimothy BFranklandMAcOluwaseye AOgunMDaJoann MZamparoMPHdSharonGrayMSdSrinivas RValluriPhDdKaijePanMSdFrederick JAnguloPhDdLuisJodarPhDdJohn MMcLaughlinPhDd Between Dec 14, 2020, and Aug 8, 2021, of 4 920 549 individuals assessed for eligibility, we included 3 436 957 (median age 45 years [IQR 29–61]; 1 799 395 [52·4%] female and 1 637 394 [47·6%] male). For fully vaccinated individuals, effectiveness against SARS-CoV-2 infections was 73% (95% CI 72–74) […]

New England Journal of Medicine

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Published Articles COOVID 2021 A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. https://www.nejm.org/coronavirus?query=main_nav_lg Covid-19 Vaccine Resource Center A collection of resources on Covid-19 vaccines, including published research, continuing medical education, and commentary.  https://www.nejm.org/covid-vaccine

Something Really Strange Is Happening At Hospitals All Over America

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Authors: Authored by Michael Snyder via TheMostImportantNews.com, TURSDAY, NOV 04, 2021 – 05:11 In a year that has been filled with so many mysteries already, I have another very odd one to share with you.  Emergency rooms are filled to overflowing all over America, and nobody can seem to explain why this is happening.  Right now, the […]

Latest Lancet Study Exposes Limits Of Vaccines At Preventing COVID Infection

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FRIDAY, OCT 29, 2021 – 05:45 PM The Lancet has just released another study comparing the efficacy of COVID vaccines to the efficacy of protection provided by previous COVID infections. Their conclusion: while vaccines lower the risk of infections with the delta variant within households, those who are fully vaccinated are still vulnerable to a […]

Inside the life of a COVID long-hauler who “fought like an animal” to make it out of the hospital after 299 days

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OCTOBER 27, 2021 / 10:44 AM / CBS NEWS The past year has seen some dramatic swings in America’s fight against COVID-19. But while the number of COVID cases are trending downward, some long-haulers are having a hard time recovering from the disease.  Alex Castro of Sandy, Oregon, used to be able to swim, cook and hike, but now […]