Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

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Authors: Lina Ma1, View ORCID ProfileSanjaya K. Sahu1, View ORCID ProfileMarlene Cano1, Vasanthan Kuppuswamy2, Jamal Bajwa1,3, View ORCID ProfileJa’Nia McPhatter1,4 Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2 infection. However, it remains to be determined whether increased complement activation is a broad indicator of critical illness (and thus, no different in COVID-19). It is also unclear which […]

Sars cov 2 drives jak1 2 dependent local complement hyperactivation

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Authors: Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry receptor for the disease-causing virus SARS-CoV-2, is highly expressed in the aforementioned tissues. However, the pathways that underlie the disease are still poorly understood. Here, […]

Biden team’s misguided and deadly COVID-19 vaccine strategy

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Vaccination ‘arms race’ could prove dangerous to the American public Authors: Dr. Robert Malone and Peter Navarro The Biden administration’s strategy to universally vaccinate in the middle of the pandemic is bad science and badly needs a reboot. This strategy will likely prolong the most dangerous phase of the worst pandemic since 1918 and almost […]

Complement control for COVID-19

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Authors: Markus Bosmann1,2,3,4,* The complement system is an integral part of innate immune defense. It consists of about 50 proteins in plasma, on cell surfaces, and inside host cells. The traditional view is that complement proteins guard the local extracellular spaces and systemic bloodstream against invading pathogens. Loss-of-function mutations resulting in terminal complement pathway deficiencies […]

SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

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Authors: Yuichiro J. Suzuki,a,⁎ Sofia I. Nikolaienko,b Vyacheslav A. Dibrova,b Yulia V. Dibrova,b Volodymyr M. Vasylyk,c Mykhailo Y. Novikov,d Nataliia V. Shults,a and Sergiy G. Gychkab Currently, the world is suffering from the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter the host cells. So […]

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

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Authors: Gloria F. Gerber,1 Xuan Yuan,1 Jia Yu,1 Benjamin A.Y. Cher,2 Evan M. Braunstein,1 Shruti Chaturvedi,1 and Robert A. Brodsky1,* Complement has emerged as a likely driver of the immune response and end-organ damage in COVID-19. In patients with severe disease, deposition of terminal complement and microthrombosis have been observed in the lung, skin, kidney, and heart.1, 2, 3, 4 Recently, we demonstrated that the severe […]

Review the safety of Covid-19 mRNA vaccines: a review

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Authors: Pratibha Anand 1, Vincent P Stahel 2 Abstract The novel coronavirus disease 2019 (COVID-19) has infected more than 100 million people globally within the first year of the pandemic. With a death toll surpassing 500,000 in the United States alone, containing the pandemic is predicated on achieving herd immunity on a global scale. This implies that at […]

Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials

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Authors: Musha Chen, Yue Yuan, Yiguo Zhou, Zhaomin Deng, Jin Zhao, Fengling Feng, Huachun Zou & Caijun Sun  Background Various modalities of vaccines against coronavirus disease 2019 (COVID-19), based on different platforms and immunization procedures, have been successively approved for marketing worldwide. A comprehensive review for clinical trials assessing the safety of COVID-19 vaccines is urgently needed to make an accurate judgment for […]

COVID-19 Vaccine Safety in Adolescents Aged 12–17 Years — United States, December 14, 2020–July 16, 2021

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Authors: Anne M. Hause, PhD1; Julianne Gee, MPH1; James Baggs, PhD1; Winston E. Abara, MD1; Paige Marquez, MSPH1; Deborah Thompson, MD2; John R. Su, MD, PhD1; Charles Licata, PhD1; Hannah G. Rosenblum, MD1,3; Tanya R. Myers, PhD1; Tom T. Shimabukuro, MD1; David K. Shay, MD1  Summary What is already known about this topic? In preauthorization […]

ADVERSE EFFECTS OF MESSENGER RNA VACCINES: An Evidence Review from the Penn Medicine Center for Evidence-based Practice

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Authors: Project director: Nikhil K. Mull, MD (CEP), Lead analyst: Matthew D. Mitchell, PhD (CEP), Clinical review: Patrick J. Brennan, MD. (CMO) EVIDENCE SUMMARY: 1. There are no specific guidelines for use of messenger RNA (mRNA) vaccines or contraindications to mRNA vaccines.2. No large trials of any mRNA vaccine have been completed yet.3. The only […]