SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy

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Authors: C. Ferreras1†, B. Pascual-Miguel1†, C. Mestre-Durán1, A. Navarro-Zapata1, L. Clares-Villa1, C. Martín-Cortázar1, R. De Paz2, A. Marcos2, J. L. Vicario3, A. Balas3, F. García-Sánchez3, C. Eguizabal4,5, C. Solano6, M. Mora-Rillo7, B. Soria8,9 and A. Pérez-Martínez1,10,11* Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus’ complete eradication. In the absence of effective vaccines, we need effective treatments with low adverse effects that can […]

Can COVID-19 Immunity Last for Years?

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Authors: Christina Aungst, PharmD Key takeaways: People who were sick with COVID-19 and recovered might have long-term immunity that lasts for months or years. We don’t know how long vaccine immunity lasts yet, but it is much safer to gain immunity from the vaccine than from getting COVID-19. Experts believe the vaccine will still work […]

COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options

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Authors: Larissa E van Eijk, 1 , † Mathijs Binkhorst, 2 , † Arno R Bourgonje, 3 , ‡ Annette K Offringa, 4 , ‡ Douwe J Mulder, 5 Eelke M Bos, 6 Nikola Kolundzic, 7 , 8 Amaal E Abdulle, 5 Peter HJ van der Voort, 9 Marcel GM Olde Rikkert, 10 Johannes G van der Hoeven, 11 Wilfred FA den Dunnen, 1 Jan‐Luuk Hillebrands, 1 , § and Harry van Goor 1 , § Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues […]

VAERS COVID Vaccine Data

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https://www.openvaers.com/covid-data Important Things To Know About VAERS VAERS is an early warning system used to monitor adverse events that happen after vaccination. VAERS is the frontline system of a comprehensive vaccine safety monitoring program in the United States. It is one of several systems CDC and the US Food and Drug Administration (FDA) use to help ensure all […]

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

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Authors: Williamson, Jack A. Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D. Davidson, David A. Matthews & Wendy S. Barclay SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin. Using lentiviral pseudotypes […]

Dr. Charles Hoffe issues Vaccine warning… Deep dive on endothelial damage to blood vessels…

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Author: Dr. Charles Hoffe in a Coronavirus, that spike protein becomes part of the viral capsule. In other words, the cell wall around the virus, called the viral capsule. But it’s not in the virus. It’s in your cells. So it therefore becomes part of the cell wall of your vascular endothelium. Which means that […]

Johns Hopkins Physician — The Power of Natural Covid Immunity…

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Authors: Johns Hopkins Dr. Marty Makary The news about the U.S. Covid pandemic is even better than you’ve heard. Some 80% to 85% of American adults are immune to the virus: More than 64% have received at least one vaccine dose and, of those who haven’t, roughly half have natural immunity from prior infection. There’s […]

Eye scan could determine whether COVID patients will be ‘long haulers’

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Authors: by Study Finds Long COVID” continues to confound doctors as patients still struggle with debilitating symptoms months after first being infection. A new study now suggests that COVID patients who could be long-haulers could be diagnosed by taking a close look at their eyes. Nerve fiber loss and an increase in key immune cells […]

What Is the D-Dimer Test?

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Authors: Richard N. Fogoros, MD The D-dimer test is a blood test that indicates whether blood clots are being actively formed somewhere within a person’s vascular system. This test is most often helpful in the diagnosis of pulmonary embolus and deep vein thrombosis, but it can also be useful in diagnosing other medical conditions in which blood clots play a […]

Never ignore extremely elevated D-dimer levels: they are specific for serious illness

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Authors: T Schutte 1, A Thijs, Y M Smulders D-dimer is routinely measured as part of the clinical diagnosis algorithms for venous thromboembolism (VTE). In these algorithms, low D- dimer cut-off values are used to generate a dichotomous test result that is sensitive, but very non-specific for VTE. A consequence of any test dichotomisation is loss of information […]