Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents A Systematic Review

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Authors: Riccardo Castagnoli, MD1,2; Martina Votto, MD1,2; Amelia Licari, MD1,2; et al Key Points Question  What are the clinical features of pediatric patients with coronavirus disease 2019 (COVID-19)? Findings  In this systematic review of 18 studies with 1065 participants, most pediatric patients with SARS-CoV-2 infection presented with fever, dry cough, and fatigue or were asymptomatic; 1 infant presented with pneumonia, complicated by shock and kidney failure, […]

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) – anatomic pathology perspective on current knowledge

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Authors: Sambit K. Mohanty, Abhishek Satapathy, Machita M. Naidu, Sanjay Mukhopadhyay, Shivani Sharma, Lisa M. Barton, Edana Stroberg, Eric J. Duval, Dinesh Pradhan, Alexandar Tzankov & Anil V. Parwani  Abstract Background The world is currently witnessing a major devastating pandemic of Coronavirus disease-2019 (COVID-19). This disease is caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). It primarily affects the respiratory tract and […]

COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

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Authors: Anant Parasher Abstract Background The severe acute respiratory syndrome (SARS) coronavirus-2 is a novel coronavirus belonging to the family Coronaviridae and is now known to be responsible for the outbreak of a series of recent acute atypical respiratory infections originating in Wuhan, China. The disease caused by this virus, termed coronavirus disease 19 or simply […]

The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review

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Authors: Shiqian Huang, Shuai Zhao, Huilin Luo, Zhouyang Wu, Jing Wu, Haifa Xia & Xiangdong Chen BMC Pulmonary Medicine volume 21, Article number: 116 (2021) Abstract Extracorporeal life support treatments such as extracorporeal membrane oxygenation (ECMO) have been recommended for the treatment of severe acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). To date, many countries, including China, have adopted ECMO as a treatment for […]

The Severe Acute Respiratory Syndrome

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Authors: Joseph S.M. Peiris, M.D., D.Phil., Kwok Y. Yuen, M.D., Albert D.M.E. Osterhaus, Ph.D., and Klaus Stöhr, Ph.D. The severe acute respiratory syndrome (SARS) is responsible for the first pandemic of the 21st century. Within months after its emergence in Guangdong Province in mainland China, it had affected more than 8000 patients and caused 774 deaths in 26 […]

Rapid detection of novel coronavirus/Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by reverse transcription-loop-mediated isothermal amplification

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Authors: Laura E. Lamb ,Sarah N. Bartolone,Elijah Ward,Michael B. Chancellor Abstract Novel Corona virus/Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or 2019-nCoV), and the subsequent disease caused by the virus (coronavirus disease 2019 or COVID-19), is an emerging global health concern that requires a rapid diagnostic test. Quantitative reverse transcription PCR (qRT-PCR) is currently the standard […]

Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider

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Authors: Aurélie Najm1, http://orcid.org/0000-0003-1105-5640Alessia Alunno2, Xavier Mariette3,4, http://orcid.org/0000-0001-6612-7336Benjamin Terrier5,6, http://orcid.org/0000-0003-2406-161XGabriele De Marco7,8, Jenny Emmel9, Laura Mason9, Dennis G McGonagle7,10 and http://orcid.org/0000-0002-8411-7972Pedro M Machado11,12,13 Abstract Background The SARS-CoV-2 pandemic is a global health problem. Beside the specific pathogenic effect of SARS-CoV-2, incompletely understood deleterious and aberrant host immune responses play critical roles in severe disease. Our objective was to summarise the available information on the pathophysiology […]

COVID-19 pathophysiology: A review

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Authors: COVID-19 pathophysiology: A review Koichi Yuki,⁎ Miho Fujiogi, and Sophia Koutsogiannaki Abstract In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused by this virus was termed COVID-19. The virus is transmittable between humans and has caused pandemic worldwide. The […]

Acute Respiratory Distress Syndrome and COVID-19: A Scoping Review and Meta-analysis

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Authors: Mehdi Jafari-Oori 1, Fatemeh Ghasemifard 2, Abbas Ebadi 3, Leila Karimi 3, Farshid Rahimi-Bashar 4, Tannaz Jamialahmadi 5 6, Paul C Guest 7, Amir Vahedian-Azimi 8, Amirhossein Sahebkar 9 10 11 12 Abstract Acute respiratory distress syndrome (ARDS) is a fatal complication of the new severe acute respiratory syndrome coronavirus (SARS-CoV-2), which causes COVID-19 disease. This scoping review was carried out with international, peer-reviewed research studies and gray literature published up to July 2020 in […]

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19

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Authors: Stephanie Seneff1and Greg Nigh21Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge MA, 02139, USA, E-mail: seneff@csail.mit.edu 2Naturopathic Oncology, Immersion Health, Portland, OR 97214, USA ABSTRACT Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which […]