Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

The Most Important Question About Long COVID

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And why answering it holds the key to treating and preventing this condition and others like it By EKATERINA PESHEVA August 9, 2023 Research Harvard Medical School The underlying mechanisms fueling long COVID continue to bedevil researchers. The syndrome presents with remarkable variation across individuals and can involve different organs with varying degrees of severity. What causes […]

Hearing Loss Is a Side Effect of COVID-19

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·April 14, 2023 Candy Gibson, Kim Gibson et al. BMJ Case Reports; Auditory Neuroscience Featured Neuroscience Summary: A link has been discovered between COVID-19 infection and sudden sensorineural hearing loss (SSHL). Upto one-third of patients referred to audiologists for SSHL were previously diagnosed with COVID-19. Other studies report an increase in SSHL in those with asymptomatic COVID-19 […]

COVID Tongue: How a Swollen Tongue Could Indicate COVID-19

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Should you be examining your tongue? Here’s how to tell if it’s COVID tongue and how to treat it. By  Korin Miller September 22, 2023; Medically reviewed by  Michael Menna, DO HEALTH You may have heard of COVID-19 causing loss of taste and smell, COVID toes, and unusual skin rashes, but did you know COVID can affect […]

Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients

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Kiran Thapaliya, 1 , 2 , * Sonya Marshall-Gradisnik, 1 Markus Barth, 2 , 3 Natalie Eaton-Fitch, 1 and Leighton Barnden 1 Front Neurosci. 2023; 17: 1125208. Published online 2023 Mar 2. doi: 10.3389/fnins.2023.1125208 PMCID: PMC10017877 PMID: 36937672 Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID patients have overlapping neurological, autonomic, pain, and post-exertional symptoms. We compared volumes of brainstem regions for 10 ME/CFS (CCC or ICC criteria), 8 long COVID (WHO […]

False, Misleading Information About COVID-19 Vaccines And Myocarditis Spreads Widely

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SEP 27, 2023 Authored by Zachary Stieber The Epoch Times  False and misleading information about COVID-19 vaccines and heart inflammation is being spread widely, including by doctors. That includes claims that data clearly show myocarditis, or heart inflammation, is more prevalent after COVID-19 infection when compared to COVID-19 vaccination. “Teen boys have been up to […]

A blood test for long Covid is possible, a study suggests

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Scientists can now show key differences in the blood of those who recover from Covid — and those who don’t. Sept. 25, 2023, 11:01 AM EDT By Erika Edwards NBC Health More than three years into the pandemic, the millions of people who have suffered from long Covid finally have scientific proof that their condition is […]

Vaccine-induced immune thrombotic thrombocytopenia

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BLOOD SPOTLIGHT| APRIL 6, 2023 Douglas B. Cines, Andreas Greinacher Blood (2023) 141 (14): 1659–1665. https://doi.org/10.1182/blood.2022017696 Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were identified. Similarities between this syndrome, vaccine-induced immune thrombotic thrombocytopenia (VITT), and heparin-induced […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

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David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, Luigi Zecca, Alessandro Sette, Luigi Bubacco, Olimpia Meucci, Elena Moro, Ashley S. Harms, Yaqian Xu, Stanley Fahn & K. Ray Chaudhuri  npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus […]

COVID-19 can trigger auto-immune disorders-related antibodies, causing thrombosis and other complications

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SEPTEMBER 12, 2023 by Maria Fernanda Ziegler, FAPESP Medical Express An article published in npj Aging reveals that natural production of auto-antibodies increases with age, and that infection by SARS-CoV-2 can exacerbate production of auto-antibodies relating to auto-immune diseases, helping to explain why aging increases the chances of developing severe COVID-19. The study also discovered some of the factors that […]