Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

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Siriruk Changrob,1 Peter J. Halfmann,2 Hejun Liu,3 Jonathan L. Torres,3 Joshua J.C. McGrath,1 Gabriel Ozorowski,3 Lei Li,1 G. Dewey Wilbanks,1 Makoto Kuroda,2 Tadashi Maemura,2 Min Huang,1 Nai-Ying Zheng,1 Hannah L. Turner,3 Steven A. Erickson,4 Yanbin Fu,1 Atsuhiro Yasuhara,1 Gagandeep Singh,5,6 Brian Monahan,6,7 Jacob Mauldin,6,7 Komal Srivastava,6,7 Viviana Simon,5,6,7,8,9 Florian Krammer,5,6,7 D. Noah Sather,10,11,12 Andrew B. Ward,3 Ian A. Wilson,3,13 Yoshihiro Kawaoka,2,14,15,16 and Patrick C. Wilson1,Published 2023 – 10.1172/JCI166844 Abstract The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants […]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

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James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 – 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side […]

Does the SARS-CoV-2 spike really have an Achilles heel?

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Shiv Pillai, Published , 2023 – More infoView PDF , 10.1172/JCI168080 Abstract The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a […]

The intersection of COVID-19 and autoimmunity

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Jason S. Knight,1 Roberto Caricchio,2 Jean-Laurent Casanova,3,4,5,6 Alexis J. Combes,7 Betty Diamond,8 Sharon E. Fox,9,10 David A. Hanauer,11 Judith A. James,12 Yogendra Kanthi,13 Virginia Ladd,14 Puja Mehta,15 Aaron M. Ring,16 Ignacio Sanz,17 Carlo Selmi,18,19 Russell P. Tracy,20 Paul J. Utz,21 Catriona A. Wagner,14 Julia Y. Wang,22 and William J. McCune1,Published October 28, 2021 – Free access | 10.1172/JCI154886 Acute COVID-19, caused by SARS-CoV-2, is characterized by diverse clinical presentations, ranging from asymptomatic infection to fatal respiratory […]

Excess Deaths Associated with COVID-19

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Provisional Death Counts for COVID-19 NOTICE: THIS WEBSITE WAS ARCHIVED ON SEPTEMBER 27, 2023.Datasets linked on this page are available on data.cdc.gov. Please note that these datasets will no longer be updated after September 27, 2023. Provisional data is available on CDC WONDER (wonder.cdc.gov). Data are updated weekly, and users can query data by a […]

COVID Pandemic Caused Collective Trauma in Americans, Survey Says

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Americans are more stressed than before, and experts blame COVID Published 11/03/23, Mansur Shaheen, The Messenger COVID Pandemic Caused Collective Trauma in Americans, Survey Says Americans, and specifically younger people, are much more stressed now than they were in years past. Experts say this is because of collective trauma experienced during the pandemic. A survey published Thursday […]

Ventilator-associated pneumonia in ICU patients with severe pneumonia and respiratory failure

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Sarah Jackson Published June 15, 2023 – 10.1172/JCI172643 The Journal of Clinical Medicine The COVID-19 pandemic resulted in an unprecedented number of patients hospitalized in intensive care units (ICUs) because of severe SARS-CoV-2 infection (1). Respiratory failure in ICU patients, whether due to respiratory infection or other causes, may necessitate mechanical ventilation if oxygen levels cannot […]

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

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Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. https://doi.org/10.1172/JCI171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]

Systemic and organ-specific immune-related manifestations of COVID-19

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Manuel Ramos-Casals, Pilar Brito-Zerón & Xavier Mariette Nature Reviews Rheumatology volume 17, pages315–332 (2021) Cite this article Abstract Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS-CoV-2 infection is predominantly centred on the respiratory system, some patients can develop an […]

COVID-19 Therapeutics for Nonhospitalized Patients

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Rajesh T. Gandhi, MD1; Preeti N. Malani, MD, MSJ2,3; Carlos del Rio, MD4, JAMA. 2022;327(7):617-618. doi:10.1001/jama.2022.0335 Substantial progress has been made in therapeutics for nonhospitalized patients with COVID-19, but supply of and access to treatment remain limited. This Viewpoint summarizes currently available therapeutics for nonhospitalized patients in the setting of the Omicron variant including principles for equitable allocation. Patients with mild or moderate COVID-19 […]