Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19)

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Authors: CDC New information on potential for under-detection of occult hypoxemia by pulse oximetry, especially among persons with dark skin New information on dermatologic manifestations associated with COVID-19 New information on prolonged shedding of replication-competent SARS-CoV-2 in severely immunocompromised persons New information on reports of reinfection with variant viruses Clinical Presentation, Clinical Course, Laboratory and […]

Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

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Authors: Roosecelis B. Martines, Jana M. Ritter1, Eduard Matkovic, Joy Gary, Brigid C. Bollweg, Hannah Bullock, Cynthia S. Goldsmith, Luciana Silva-Flannery, Josilene N. Seixas, Sarah Reagan-Steiner, Timothy Uyeki, Amy Denison, Julu Bhatnagar, Wun-Ju Shieh, Sherif R. Zaki, and COVID-19 Pathology Working Group An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe […]

Top Ten COVID-19 Anxiety Reduction Strategies

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Authors: Ken Goodman, LCSW To stop the spread of COVID-19, we’ve had to practice social distancing. But to stop the spread of anxiety, we must distance ourselves from the media. All anxiety stems from uncertainty and an active imagination which produces catastrophic thoughts. The media, which is 24/7 Coronavirus and virtually all negative, is the […]

Considerations for Certain Concomitant Medications in Patients With COVID-19

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Authors: NIH Patients with COVID-19 who are receiving concomitant medications (e.g., angiotensin-converting enzyme [ACE] inhibitors, angiotensin receptor blockers [ARBs], statins, systemic or inhaled corticosteroids, nonsteroidal anti-inflammatory drugs, acid-suppressive therapy) for underlying medical conditions should not discontinue these medications during acute management of COVID-19 unless discontinuation is otherwise warranted by their clinical condition (AIIa for ACE inhibitors and […]

Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression

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Authors: Mary Kathryn Bohn, Alexandra Hall, Lusia Sepiashvili, Benjamin Jung, Shannon Steele, and Khosrow Adeli Abstract The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This […]

Complications Coronavirus Can Cause

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Authors: WebMD If you have COVID-19, the illness that comes from infection with the recently discovered coronavirus, your symptoms may be relatively mild and manageable at home. That’s true for most people. But if you’re older or have another illness such as diabetes or heart disease, you’re more at risk for the serious form of COVID-19. Some people — about 1 […]

Interferons (Alfa, Beta)

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Authors: NIH Interferons are a family of cytokines with antiviral properties. They have been suggested as a potential treatment for COVID-19 because of their in vitro and in vivo antiviral properties. Recommendation The COVID-19 Treatment Guidelines Panel recommends against the use of interferons for the treatment of patients with severe or critical COVID-19, except in a clinical trial (AIII). There is insufficient evidence to […]

Cytokine Storm

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Authors: David C. Fajgenbaum, M.D., and Carl H. June, M.D. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reminded us of the critical role of an effective host immune response and the devastating effect of immune dysregulation. This year marks 10 years since the first description of a cytokine storm that developed after chimeric […]

Ivermectin

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Authors: NIH Ivermectin is a Food and Drug Administration (FDA)-approved antiparasitic drug that is used to treat several neglected tropical diseases, including onchocerciasis, helminthiases, and scabies.1 It is also being evaluated for its potential to reduce the rate of malaria transmission by killing mosquitoes that feed on treated humans and livestock.2 For these indications, ivermectin has been […]

OBGYN explains why a COVID vaccine might affect menstrual cycles

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Authors: Kate Larsen SAN FRANCISCO — Anecdotal evidence from women around the country has led to questions about how COVID-19 vaccines may affect women’s menstrual cycles. When ABC7 News reporter, Kate Larsen, posted the question on social media, it became clear that a lot of women are experiencing cycle changes, and are wondering if it’s […]